Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. / Novikova, Nataliia Sergeevna; Diatlova, Anastasiia Sergeevna; Derevtsova, Kristina Zurabovna; Korneva, Elena Andreevna; Fedotkina, Tamara Viktorovna; Ostrinki, Yuri; Abraham, Lital; Quinn, Shir; Segal, Yahel; Churilov, Leonid; Blank, Miri; Shoenfeld, Yehuda; Aharoni, Rina; Amital, Howard.
в: Journal of Neuroimmunology, Том 337, 577070, 15.12.2019, стр. 577070.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis
AU - Novikova, Nataliia Sergeevna
AU - Diatlova, Anastasiia Sergeevna
AU - Derevtsova, Kristina Zurabovna
AU - Korneva, Elena Andreevna
AU - Fedotkina, Tamara Viktorovna
AU - Ostrinki, Yuri
AU - Abraham, Lital
AU - Quinn, Shir
AU - Segal, Yahel
AU - Churilov, Leonid
AU - Blank, Miri
AU - Shoenfeld, Yehuda
AU - Aharoni, Rina
AU - Amital, Howard
N1 - Publisher Copyright: © 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/12/15
Y1 - 2019/12/15
N2 - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.
AB - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.
KW - Tuftsin-phosphorylcholine
KW - Experimental autoimmune encephalomyelitis
KW - AutoimmunityMultiple sclerosis
KW - Autoimmunity
KW - Multiple sclerosis
KW - HYGIENE HYPOTHESIS
KW - HELMINTHS
KW - PARASITE INFECTION
KW - ES-62
KW - MECHANISMS
KW - IMMUNOMODULATION
KW - LUPUS NEPHRITIS
KW - MULTIPLE-SCLEROSIS
KW - REMYELINATION
KW - MODULATION
UR - http://www.scopus.com/inward/record.url?scp=85074187367&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/tuftsinphosphorylcholine-attenuate-experimental-autoimmune-encephalomyelitis
U2 - 10.1016/j.jneuroim.2019.577070
DO - 10.1016/j.jneuroim.2019.577070
M3 - Article
C2 - 31683117
VL - 337
SP - 577070
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
M1 - 577070
ER -
ID: 48579107