DOI

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

Язык оригиналаанглийский
Номер статьи577070
Страницы (с-по)577070
Число страниц8
ЖурналJournal of Neuroimmunology
Том337
Дата раннего онлайн-доступа24 окт 2019
DOI
СостояниеОпубликовано - 15 дек 2019

    Предметные области Scopus

  • Клиническая неврология
  • Неврология
  • Иммунология и аллергии
  • Иммунология

ID: 48579107