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Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. / Novikova, Nataliia Sergeevna; Diatlova, Anastasiia Sergeevna; Derevtsova, Kristina Zurabovna; Korneva, Elena Andreevna; Fedotkina, Tamara Viktorovna; Ostrinki, Yuri; Abraham, Lital; Quinn, Shir; Segal, Yahel; Churilov, Leonid; Blank, Miri; Shoenfeld, Yehuda; Aharoni, Rina; Amital, Howard.

In: Journal of Neuroimmunology, Vol. 337, 577070, 15.12.2019, p. 577070.

Research output: Contribution to journal › Article › peer-review

Harvard

Novikova, NS, Diatlova, AS, Derevtsova, KZ, Korneva, EA, Fedotkina, TV, Ostrinki, Y, Abraham, L, Quinn, S, Segal, Y, Churilov, L, Blank, M, Shoenfeld, Y, Aharoni, R & Amital, H 2019, 'Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis', Journal of Neuroimmunology, vol. 337, 577070, pp. 577070. https://doi.org/10.1016/j.jneuroim.2019.577070

APA

Novikova, N. S., Diatlova, A. S., Derevtsova, K. Z., Korneva, E. A., Fedotkina, T. V., Ostrinki, Y., Abraham, L., Quinn, S., Segal, Y., Churilov, L., Blank, M., Shoenfeld, Y., Aharoni, R., & Amital, H. (2019). Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 337, 577070. [577070]. https://doi.org/10.1016/j.jneuroim.2019.577070

Vancouver

Novikova NS, Diatlova AS, Derevtsova KZ, Korneva EA, Fedotkina TV, Ostrinki Y et al. Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 2019 Dec 15;337:577070. 577070. https://doi.org/10.1016/j.jneuroim.2019.577070

Author

Novikova, Nataliia Sergeevna ; Diatlova, Anastasiia Sergeevna ; Derevtsova, Kristina Zurabovna ; Korneva, Elena Andreevna ; Fedotkina, Tamara Viktorovna ; Ostrinki, Yuri ; Abraham, Lital ; Quinn, Shir ; Segal, Yahel ; Churilov, Leonid ; Blank, Miri ; Shoenfeld, Yehuda ; Aharoni, Rina ; Amital, Howard. / Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. In: Journal of Neuroimmunology. 2019 ; Vol. 337. pp. 577070.

BibTeX

@article{c2b7be5b66ce48b3a3030e3351a518cc,
title = "Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis",
abstract = "Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.",
keywords = "Tuftsin-phosphorylcholine, Experimental autoimmune encephalomyelitis, AutoimmunityMultiple sclerosis, Autoimmunity, Multiple sclerosis, HYGIENE HYPOTHESIS, HELMINTHS, PARASITE INFECTION, ES-62, MECHANISMS, IMMUNOMODULATION, LUPUS NEPHRITIS, MULTIPLE-SCLEROSIS, REMYELINATION, MODULATION",
author = "Novikova, {Nataliia Sergeevna} and Diatlova, {Anastasiia Sergeevna} and Derevtsova, {Kristina Zurabovna} and Korneva, {Elena Andreevna} and Fedotkina, {Tamara Viktorovna} and Yuri Ostrinki and Lital Abraham and Shir Quinn and Yahel Segal and Leonid Churilov and Miri Blank and Yehuda Shoenfeld and Rina Aharoni and Howard Amital",
note = "Publisher Copyright: {\textcopyright} 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
month = dec,
day = "15",
doi = "10.1016/j.jneuroim.2019.577070",
language = "English",
volume = "337",
pages = "577070",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

AU - Novikova, Nataliia Sergeevna

AU - Diatlova, Anastasiia Sergeevna

AU - Derevtsova, Kristina Zurabovna

AU - Korneva, Elena Andreevna

AU - Fedotkina, Tamara Viktorovna

AU - Ostrinki, Yuri

AU - Abraham, Lital

AU - Quinn, Shir

AU - Segal, Yahel

AU - Churilov, Leonid

AU - Blank, Miri

AU - Shoenfeld, Yehuda

AU - Aharoni, Rina

AU - Amital, Howard

N1 - Publisher Copyright: © 2019 Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/12/15

Y1 - 2019/12/15

N2 - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

AB - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

KW - Tuftsin-phosphorylcholine

KW - Experimental autoimmune encephalomyelitis

KW - AutoimmunityMultiple sclerosis

KW - Autoimmunity

KW - Multiple sclerosis

KW - HYGIENE HYPOTHESIS

KW - HELMINTHS

KW - PARASITE INFECTION

KW - ES-62

KW - MECHANISMS

KW - IMMUNOMODULATION

KW - LUPUS NEPHRITIS

KW - MULTIPLE-SCLEROSIS

KW - REMYELINATION

KW - MODULATION

UR - http://www.scopus.com/inward/record.url?scp=85074187367&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/tuftsinphosphorylcholine-attenuate-experimental-autoimmune-encephalomyelitis

U2 - 10.1016/j.jneuroim.2019.577070

DO - 10.1016/j.jneuroim.2019.577070

M3 - Article

C2 - 31683117

VL - 337

SP - 577070

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577070

ER -

ID: 48579107