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Preliminary associations between childhood neglect, MIF, and cortisol : Potential pathways to long-term disease risk. / Bick, Johanna; Nguyen, Victoria; Leng, Lin; Piecychna, Marta; Crowley, Michael J.; Bucala, Richard; Mayes, Linda C.; Grigorenko, Elena L.

в: Developmental Psychobiology, Том 57, № 1, 01.01.2015, стр. 131-139.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Bick, J, Nguyen, V, Leng, L, Piecychna, M, Crowley, MJ, Bucala, R, Mayes, LC & Grigorenko, EL 2015, 'Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to long-term disease risk', Developmental Psychobiology, Том. 57, № 1, стр. 131-139. https://doi.org/10.1002/dev.21265

APA

Bick, J., Nguyen, V., Leng, L., Piecychna, M., Crowley, M. J., Bucala, R., Mayes, L. C., & Grigorenko, E. L. (2015). Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to long-term disease risk. Developmental Psychobiology, 57(1), 131-139. https://doi.org/10.1002/dev.21265

Vancouver

Bick J, Nguyen V, Leng L, Piecychna M, Crowley MJ, Bucala R и пр. Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to long-term disease risk. Developmental Psychobiology. 2015 Янв. 1;57(1):131-139. https://doi.org/10.1002/dev.21265

Author

Bick, Johanna ; Nguyen, Victoria ; Leng, Lin ; Piecychna, Marta ; Crowley, Michael J. ; Bucala, Richard ; Mayes, Linda C. ; Grigorenko, Elena L. / Preliminary associations between childhood neglect, MIF, and cortisol : Potential pathways to long-term disease risk. в: Developmental Psychobiology. 2015 ; Том 57, № 1. стр. 131-139.

BibTeX

@article{0ecc94f3830d4a18857cdf6fbb6a91b7,
title = "Preliminary associations between childhood neglect, MIF, and cortisol: Potential pathways to long-term disease risk",
abstract = "The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.",
keywords = "Adolescent, HPA axis, Immune system, Parental care, Stress",
author = "Johanna Bick and Victoria Nguyen and Lin Leng and Marta Piecychna and Crowley, {Michael J.} and Richard Bucala and Mayes, {Linda C.} and Grigorenko, {Elena L.}",
year = "2015",
month = jan,
day = "1",
doi = "10.1002/dev.21265",
language = "English",
volume = "57",
pages = "131--139",
journal = "Developmental Psychobiology",
issn = "0012-1630",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Preliminary associations between childhood neglect, MIF, and cortisol

T2 - Potential pathways to long-term disease risk

AU - Bick, Johanna

AU - Nguyen, Victoria

AU - Leng, Lin

AU - Piecychna, Marta

AU - Crowley, Michael J.

AU - Bucala, Richard

AU - Mayes, Linda C.

AU - Grigorenko, Elena L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.

AB - The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.

KW - Adolescent

KW - HPA axis

KW - Immune system

KW - Parental care

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=84920025502&partnerID=8YFLogxK

U2 - 10.1002/dev.21265

DO - 10.1002/dev.21265

M3 - Article

C2 - 25380347

AN - SCOPUS:84920025502

VL - 57

SP - 131

EP - 139

JO - Developmental Psychobiology

JF - Developmental Psychobiology

SN - 0012-1630

IS - 1

ER -

ID: 62755508