Preliminary associations between childhood neglect, MIF, and cortisol : Potential pathways to long-term disease risk. / Bick, Johanna; Nguyen, Victoria; Leng, Lin; Piecychna, Marta; Crowley, Michael J.; Bucala, Richard; Mayes, Linda C.; Grigorenko, Elena L.
In: Developmental Psychobiology, Vol. 57, No. 1, 01.01.2015, p. 131-139.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Preliminary associations between childhood neglect, MIF, and cortisol
T2 - Potential pathways to long-term disease risk
AU - Bick, Johanna
AU - Nguyen, Victoria
AU - Leng, Lin
AU - Piecychna, Marta
AU - Crowley, Michael J.
AU - Bucala, Richard
AU - Mayes, Linda C.
AU - Grigorenko, Elena L.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.
AB - The study examined Hypothalamus-Pituitary-Adrenal (HPA) axis and inflammatory signaling in 206 youth with histories of prenatal drug exposure and self-reported histories of maltreatment. Youth with histories of severe neglect showed elevated levels of cortisol, the end product of the HPA axis, in comparison to youth with lower or minimal levels of neglect. Histories of severe neglect also were associated with increased levels of Macrophage Migration Inhibitory Factor (MIF), a cytokine known to be intricately involved in HPA axis regulation. Salivary MIF levels also were positively associated with youth age and prenatal drug exposure. These MIF and cortisol alterations may signal pathophysiological disruptions in the neuro-endocrine and immune systems, which may lead to trajectories of increased disease risk among vulnerable youth. Our findings also provide preliminary support for the validity and reliability of a noninvasive salivary assessment of MIF.
KW - Adolescent
KW - HPA axis
KW - Immune system
KW - Parental care
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=84920025502&partnerID=8YFLogxK
U2 - 10.1002/dev.21265
DO - 10.1002/dev.21265
M3 - Article
C2 - 25380347
AN - SCOPUS:84920025502
VL - 57
SP - 131
EP - 139
JO - Developmental Psychobiology
JF - Developmental Psychobiology
SN - 0012-1630
IS - 1
ER -
ID: 62755508