TY - JOUR

T1 - PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites

AU - Степанова, Мария Анатольевна

AU - Аверьянов, Илья Валерьевич

AU - Сердобинцев, Михаил Сергеевич

AU - Гофман, Иосиф

AU - Блюм, Наталья Михайловна

AU - Семёнова, Наталья

AU - Нащекина, Юлия Александровна

AU - Виноградова, Татьяна Ивановна

AU - Коржиков-Влах, Виктор Александрович

AU - Karttunen, Mikko

AU - Коржикова-Влах, Евгения Георгиевна

N1 - Publisher Copyright: © 2019 by the authors.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.

AB - The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.

KW - нанокристаллическая целлюлоза

KW - композитные плёнки

KW - материалы на основе сложных полиэфиров

KW - механические свойства

KW - Биосовместимость

KW - Biocompatibility

KW - Composite films

KW - Mechanical properties

KW - Nanocrystalline cellulose

KW - Polyester materials

KW - CRYSTALLIZATION

KW - PLA

KW - biocompatibility

KW - CHITOSAN

KW - mechanical properties

KW - DELIVERY

KW - POLYLACTIDE

KW - composite films

KW - PEG

KW - POLY(LACTIC ACID)

KW - nanocrystalline cellulose

KW - polyester materials

UR - http://www.scopus.com/inward/record.url?scp=85074270498&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/pglumodified-nanocrystalline-cellulose-improves-mechanical-properties-biocompatibility-mineralizatio

U2 - 10.3390/ma12203435

DO - 10.3390/ma12203435

M3 - Article

C2 - 31640122

VL - 12

JO - Materials

JF - Materials

SN - 1996-1944

IS - 20

M1 - 3435

ER -