Документы

DOI

The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.

Язык оригиналаанглийский
Номер статьи3435
Число страниц19
ЖурналMaterials
Том12
Номер выпуска20
DOI
СостояниеОпубликовано - 1 окт 2019

    Предметные области Scopus

  • Керамика и композитные материалы
  • Биоинженерия
  • Пластик и полимеры
  • Коллоидная химия и химия поверхности
  • Биоматериалы
  • Материаловедение (все)

    Области исследований

  • нанокристаллическая целлюлоза, композитные плёнки, материалы на основе сложных полиэфиров, механические свойства, Биосовместимость

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