PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites. / Степанова, Мария Анатольевна; Аверьянов, Илья Валерьевич; Сердобинцев, Михаил Сергеевич; Гофман, Иосиф; Блюм, Наталья Михайловна; Семёнова, Наталья; Нащекина, Юлия Александровна; Виноградова, Татьяна Ивановна; Коржиков-Влах, Виктор Александрович; Karttunen, Mikko; Коржикова-Влах, Евгения Георгиевна.
In: Materials, Vol. 12, No. 20, 3435, 01.10.2019.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - PGlu-Modified Nanocrystalline Cellulose Improves Mechanical Properties, Biocompatibility, and Mineralization of Polyester-Based Composites
AU - Степанова, Мария Анатольевна
AU - Аверьянов, Илья Валерьевич
AU - Сердобинцев, Михаил Сергеевич
AU - Гофман, Иосиф
AU - Блюм, Наталья Михайловна
AU - Семёнова, Наталья
AU - Нащекина, Юлия Александровна
AU - Виноградова, Татьяна Ивановна
AU - Коржиков-Влах, Виктор Александрович
AU - Karttunen, Mikko
AU - Коржикова-Влах, Евгения Георгиевна
N1 - Publisher Copyright: © 2019 by the authors.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.
AB - The development of biocompatible composite materials is in high demand in many fields such as biomedicine, bioengineering, and biotechnology. In this study, two series of poly (D,L-lactide) and poly (ε-caprolactone)-based films filled with neat and modified with poly (glutamic acid) (PGlu) nanocrystalline cellulose (NCC) were prepared. An analysis of scanning electron and atomic force microscopies' results shows that the modification of NCC with poly (glutamic acid) favored the better distribution of the nanofiller in the polymer matrix. Investigating the ability of the developed materials to attract and retain calcium ions led to the conclusion that composites containing NCC modified with PGlu induced better mineralization from model solutions than composites containing neat NCC. Moreover, compared to unmodified NCC, functionalization with PGlu improved the mechanical properties of composite films. The subcutaneous implantation of these composite materials into the backs of rats and the further histological investigation of neighboring tissues revealed the better biocompatibility of polyester materials filled with NCC-PGlu.
KW - нанокристаллическая целлюлоза
KW - композитные плёнки
KW - материалы на основе сложных полиэфиров
KW - механические свойства
KW - Биосовместимость
KW - Biocompatibility
KW - Composite films
KW - Mechanical properties
KW - Nanocrystalline cellulose
KW - Polyester materials
KW - CRYSTALLIZATION
KW - PLA
KW - biocompatibility
KW - CHITOSAN
KW - mechanical properties
KW - DELIVERY
KW - POLYLACTIDE
KW - composite films
KW - PEG
KW - POLY(LACTIC ACID)
KW - nanocrystalline cellulose
KW - polyester materials
UR - http://www.scopus.com/inward/record.url?scp=85074270498&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/pglumodified-nanocrystalline-cellulose-improves-mechanical-properties-biocompatibility-mineralizatio
U2 - 10.3390/ma12203435
DO - 10.3390/ma12203435
M3 - Article
C2 - 31640122
VL - 12
JO - Materials
JF - Materials
SN - 1996-1944
IS - 20
M1 - 3435
ER -
ID: 47669830