Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period. / Zykin, P A; Moiseenko, I A; Tkachenko, L A; Nasyrov, R A; Tsvetkov, E A; Krasnoshchekova, E I.
в: Bulletin of Experimental Biology and Medicine, Том 164, № 4, 03.2018, стр. 497-501.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period
AU - Zykin, P A
AU - Moiseenko, I A
AU - Tkachenko, L A
AU - Nasyrov, R A
AU - Tsvetkov, E A
AU - Krasnoshchekova, E I
PY - 2018/3
Y1 - 2018/3
N2 - We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+neurons only in layer III, and the unique layer V. Reelin+Cajal-Retzius cells and N200+fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.
AB - We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+neurons only in layer III, and the unique layer V. Reelin+Cajal-Retzius cells and N200+fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.
KW - Journal Article
KW - N200
KW - MAP2
KW - entorhial cortex
KW - prenatal development
KW - human
KW - Immunohistochemistry
KW - Humans
KW - Neurofilament Proteins/genetics
KW - Gestational Age
KW - Microtubule-Associated Proteins/genetics
KW - Entorhinal Cortex/anatomy & histology
KW - Calbindin 2/genetics
KW - Image Processing, Computer-Assisted
KW - Neurons/metabolism
KW - Parvalbumins/genetics
KW - Gene Expression Regulation, Developmental
KW - Calbindins/genetics
KW - Fetus
KW - Asphyxia/metabolism
KW - Microtomy
KW - CALCIUM-BINDING PROTEINS
KW - HUMAN CEREBRAL-CORTEX
UR - http://www.scopus.com/inward/record.url?scp=85042790430&partnerID=8YFLogxK
U2 - 10.1007/s10517-018-4020-2
DO - 10.1007/s10517-018-4020-2
M3 - Article
C2 - 29504096
VL - 164
SP - 497
EP - 501
JO - Bulletin of Experimental Biology and Medicine
JF - Bulletin of Experimental Biology and Medicine
SN - 0007-4888
IS - 4
ER -
ID: 16267882