Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period

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Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period. / Zykin, P A; Moiseenko, I A; Tkachenko, L A; Nasyrov, R A; Tsvetkov, E A; Krasnoshchekova, E I.

In: Bulletin of Experimental Biology and Medicine, Vol. 164, No. 4, 03.2018, p. 497-501.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{9cc1b9eda9044abfbf1d7f8310739405,

title = "Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period",

abstract = "We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+neurons only in layer III, and the unique layer V. Reelin+Cajal-Retzius cells and N200+fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.",

keywords = "Journal Article, N200, MAP2, entorhial cortex, prenatal development, human, Immunohistochemistry, Humans, Neurofilament Proteins/genetics, Gestational Age, Microtubule-Associated Proteins/genetics, Entorhinal Cortex/anatomy & histology, Calbindin 2/genetics, Image Processing, Computer-Assisted, Neurons/metabolism, Parvalbumins/genetics, Gene Expression Regulation, Developmental, Calbindins/genetics, Fetus, Asphyxia/metabolism, Microtomy, CALCIUM-BINDING PROTEINS, HUMAN CEREBRAL-CORTEX",

author = "Zykin, {P A} and Moiseenko, {I A} and Tkachenko, {L A} and Nasyrov, {R A} and Tsvetkov, {E A} and Krasnoshchekova, {E I}",

year = "2018",

month = mar,

doi = "10.1007/s10517-018-4020-2",

language = "English",

volume = "164",

pages = "497--501",

journal = "Bulletin of Experimental Biology and Medicine",

issn = "0007-4888",

publisher = "Springer Nature",

number = "4",

}

RIS

TY - JOUR

T1 - Peculiarities of Cyto- and Chemoarchitectonics of Human Entorhinal Cortex during the Fetal Period

AU - Zykin, P A

AU - Moiseenko, I A

AU - Tkachenko, L A

AU - Nasyrov, R A

AU - Tsvetkov, E A

AU - Krasnoshchekova, E I

PY - 2018/3

Y1 - 2018/3

N2 - We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+neurons only in layer III, and the unique layer V. Reelin+Cajal-Retzius cells and N200+fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.

AB - We studied peculiarities of the structure of human entorhinal cortex at weeks 20-26 of gestation (10 hemispheres). The samples were Nissl-stained and immunohistochemically treated with antibodies to parvalbumin, calretinin, calbindin, and cytoskeleton proteins (MAP2 and N200). 3D-reconstruction of the entorhinal cortex from serial sections was performed, caudomedial and rostrolateral areas were isolated. Parvalbumin+cells in layer I, discrete distribution of layer II cells with colocalization of MAP2 and calretinin at the border with layer I, and two sublayers Va and Vb with MAP2+neurons were typical for the caudomedial area. Rostrolateral area was characterized by the homogenous layer II with big amount of cells, high density of MAP2+neurons only in layer III, and the unique layer V. Reelin+Cajal-Retzius cells and N200+fiber plexus in layer I were observed in the caudomedial and rostrolateral areas of the entorhial cortex. Layer IV was represented by a cell-free desiccant.

KW - Journal Article

KW - N200

KW - MAP2

KW - entorhial cortex

KW - prenatal development

KW - human

KW - Immunohistochemistry

KW - Humans

KW - Neurofilament Proteins/genetics

KW - Gestational Age

KW - Microtubule-Associated Proteins/genetics

KW - Entorhinal Cortex/anatomy & histology

KW - Calbindin 2/genetics

KW - Image Processing, Computer-Assisted

KW - Neurons/metabolism

KW - Parvalbumins/genetics

KW - Gene Expression Regulation, Developmental

KW - Calbindins/genetics

KW - Fetus

KW - Asphyxia/metabolism

KW - Microtomy

KW - CALCIUM-BINDING PROTEINS

KW - HUMAN CEREBRAL-CORTEX

UR - http://www.scopus.com/inward/record.url?scp=85042790430&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4020-2

DO - 10.1007/s10517-018-4020-2

M3 - Article

C2 - 29504096

VL - 164

SP - 497

EP - 501

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 4

ER -

ID: 16267882