TY - JOUR

T1 - Emotional behavior in aquatic organisms?

T2 - Lessons from crayfish and zebrafish

AU - de Abreu, Murilo S

AU - Maximino, Caio

AU - Banha, Filipe

AU - Anastácio, Pedro M

AU - Demin, Konstantin A

AU - Kalueff, Allan V

AU - Soares, Marta C

N1 - © 2019 Wiley Periodicals, Inc.

PY - 2019/11/12

Y1 - 2019/11/12

N2 - Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish- and crayfish-based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

AB - Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish- and crayfish-based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

KW - aggressiveness

KW - anxiety

KW - crayfish

KW - social preference

KW - translational research

KW - zebrafish

KW - DANIO-RERIO

KW - AGGRESSIVE-BEHAVIOR

KW - RED SWAMP CRAYFISH

KW - ANXIETY-LIKE BEHAVIOR

KW - PROCAMBARUS-FALLAX HAGEN

KW - DOMINANCE HIERARCHY FORMATION

KW - INDIVIDUAL IDENTIFICATION

KW - INVASIVE CRAYFISH

KW - SOCIAL-INTERACTION

KW - ANIMAL-MODELS

UR - http://www.scopus.com/inward/record.url?scp=85074983977&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/emotional-behavior-aquatic-organisms-lessons-crayfish-zebrafish

U2 - 10.1002/jnr.24550

DO - 10.1002/jnr.24550

M3 - Review article

C2 - 31722127

VL - 98

SP - 764

EP - 779

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 5

ER -