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DOI

  • Murilo S de Abreu
  • Caio Maximino
  • Filipe Banha
  • Pedro M Anastácio
  • Konstantin A Demin
  • Allan V Kalueff
  • Marta C Soares

Experimental animal models are a valuable tool to study the neurobiology of emotional behavior and mechanisms underlying human affective disorders. Mounting evidence suggests that various aquatic organisms, including both vertebrate (e.g., zebrafish) and invertebrate (e.g., crayfish) species, may be relevant to study animal emotional response and its deficits. Ideally, model organisms of disease should possess considerable genetic and physiological homology to mammals, display robust behavioral and physiological responses to stress, and should be sensitive to a wide range of drugs known to modulate stress and affective behaviors. Here, we summarize recent findings in the field of zebrafish- and crayfish-based tests of stress, anxiety, aggressiveness and social preference, and discuss further perspectives of using these novel model organisms in translational biological psychiatry. Outlining the remaining questions in this field, we also emphasize the need in further development and a wider use of crayfish and zebrafish models to study the pathogenesis of affective disorders.

Язык оригиналаанглийский
Страницы (с-по)764-779
Число страниц16
ЖурналJournal of Neuroscience Research
Том98
Номер выпуска5
Дата раннего онлайн-доступа2019
DOI
СостояниеОпубликовано - 12 ноя 2019

    Предметные области Scopus

  • Клеточная и молекулрная нейробиология

ID: 48951814