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Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. / Gein, V.L.; Yankin, A.N.; Nosova, N.V.; Levandovskaya, E.B.; Novikova, V.V.; Rudakova, I.P.

In: Russian Journal of General Chemistry, Vol. 89, No. 6, 01.06.2019, p. 1169-1176.

Research output: Contribution to journal › Article › peer-review

Harvard

Gein, VL, Yankin, AN, Nosova, NV, Levandovskaya, EB, Novikova, VV & Rudakova, IP 2019, 'Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives', Russian Journal of General Chemistry, vol. 89, no. 6, pp. 1169-1176. https://doi.org/10.1134/S1070363219060112

APA

Gein, V. L., Yankin, A. N., Nosova, N. V., Levandovskaya, E. B., Novikova, V. V., & Rudakova, I. P. (2019). Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. Russian Journal of General Chemistry, 89(6), 1169-1176. https://doi.org/10.1134/S1070363219060112

Vancouver

Gein VL, Yankin AN, Nosova NV, Levandovskaya EB, Novikova VV, Rudakova IP. Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. Russian Journal of General Chemistry. 2019 Jun 1;89(6):1169-1176. https://doi.org/10.1134/S1070363219060112

Author

Gein, V.L. ; Yankin, A.N. ; Nosova, N.V. ; Levandovskaya, E.B. ; Novikova, V.V. ; Rudakova, I.P. / Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. In: Russian Journal of General Chemistry. 2019 ; Vol. 89, No. 6. pp. 1169-1176.

BibTeX

@article{664b10700347422382c9501cf6d976e8,
title = "Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives",
abstract = "Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities.",
keywords = "anti-inflammatory activity, antimicrobial activity, hydrazine hydrate, hydrazones, indazoles, phenylhydrazine, GREENER APPROACH, DESIGN, INDAZOLE",
author = "V.L. Gein and A.N. Yankin and N.V. Nosova and E.B. Levandovskaya and V.V. Novikova and I.P. Rudakova",
year = "2019",
month = jun,
day = "1",
doi = "10.1134/S1070363219060112",
language = "English",
volume = "89",
pages = "1169--1176",
journal = "Russian Journal of General Chemistry",
issn = "1070-3632",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "6",

}

RIS

TY - JOUR

T1 - Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives

AU - Gein, V.L.

AU - Yankin, A.N.

AU - Nosova, N.V.

AU - Levandovskaya, E.B.

AU - Novikova, V.V.

AU - Rudakova, I.P.

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities.

AB - Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities.

KW - anti-inflammatory activity

KW - antimicrobial activity

KW - hydrazine hydrate

KW - hydrazones

KW - indazoles

KW - phenylhydrazine

KW - GREENER APPROACH

KW - DESIGN

KW - INDAZOLE

UR - http://www.scopus.com/inward/record.url?scp=85068682219&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/synthesis-biological-activity-4567tetrahydro2hindazole-derivatives

U2 - 10.1134/S1070363219060112

DO - 10.1134/S1070363219060112

M3 - Article

AN - SCOPUS:85068682219

VL - 89

SP - 1169

EP - 1176

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

SN - 1070-3632

IS - 6

ER -

ID: 45307239