Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives. / Gein, V.L.; Yankin, A.N.; Nosova, N.V.; Levandovskaya, E.B.; Novikova, V.V.; Rudakova, I.P.
в: Russian Journal of General Chemistry, Том 89, № 6, 01.06.2019, стр. 1169-1176.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis and Biological Activity of 4,5,6,7-Tetrahydro-2H-indazole Derivatives
AU - Gein, V.L.
AU - Yankin, A.N.
AU - Nosova, N.V.
AU - Levandovskaya, E.B.
AU - Novikova, V.V.
AU - Rudakova, I.P.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities.
AB - Novel 4,5,6,7-tetrahydro-2H-indazole derivatives were obtained via the reaction of N1,N3,2-triaryl-6-hydroxy-6-methyl-4-oxocyclohexane-1,3-dicarboxamides with hydrazine hydrate. The reaction of 4-oxocyclo-hexane-1,3-dicarboxamides with phenylhydrazine led to the formation of hydrazones instead of indazoles. The synthesized compounds were tested for antimicrobial, analgesic and anti-inflammatory activities.
KW - anti-inflammatory activity
KW - antimicrobial activity
KW - hydrazine hydrate
KW - hydrazones
KW - indazoles
KW - phenylhydrazine
KW - GREENER APPROACH
KW - DESIGN
KW - INDAZOLE
UR - http://www.scopus.com/inward/record.url?scp=85068682219&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/synthesis-biological-activity-4567tetrahydro2hindazole-derivatives
U2 - 10.1134/S1070363219060112
DO - 10.1134/S1070363219060112
M3 - Article
AN - SCOPUS:85068682219
VL - 89
SP - 1169
EP - 1176
JO - Russian Journal of General Chemistry
JF - Russian Journal of General Chemistry
SN - 1070-3632
IS - 6
ER -
ID: 45307239