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Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. / Mikolaichuk, O. V. ; Protas, A. V. ; Popova, E. A. ; Mukhametshina, A. V. ; Ovsepyan, G. K. ; Trifonov, R. E. .

In: Russian Chemical Bulletin, Vol. 67, No. 7, 2018, p. 1312-1315.

Research output: Contribution to journal › Article › peer-review

Harvard

Mikolaichuk, OV, Protas, AV, Popova, EA, Mukhametshina, AV, Ovsepyan, GK & Trifonov, RE 2018, 'Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands', Russian Chemical Bulletin, vol. 67, no. 7, pp. 1312-1315. https://doi.org/10.1007/s11172-018-2217-1

APA

Mikolaichuk, O. V., Protas, A. V., Popova, E. A., Mukhametshina, A. V., Ovsepyan, G. K., & Trifonov, R. E. (2018). Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russian Chemical Bulletin, 67(7), 1312-1315. https://doi.org/10.1007/s11172-018-2217-1

Vancouver

Mikolaichuk OV, Protas AV, Popova EA, Mukhametshina AV, Ovsepyan GK, Trifonov RE. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russian Chemical Bulletin. 2018;67(7):1312-1315. https://doi.org/10.1007/s11172-018-2217-1

Author

Mikolaichuk, O. V. ; Protas, A. V. ; Popova, E. A. ; Mukhametshina, A. V. ; Ovsepyan, G. K. ; Trifonov, R. E. . / Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. In: Russian Chemical Bulletin. 2018 ; Vol. 67, No. 7. pp. 1312-1315.

BibTeX

@article{d76475f1715d45f385f982b0dd222af6,
title = "Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands",
abstract = "The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA. ",
keywords = "DNA binding constants, Pt and Pd complexes, tetrazoles, tetrazolylacetic acids",
author = "Mikolaichuk, {O. V.} and Protas, {A. V.} and Popova, {E. A.} and Mukhametshina, {A. V.} and Ovsepyan, {G. K.} and Trifonov, {R. E.}",
note = "Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1",
year = "2018",
doi = "10.1007/s11172-018-2217-1",
language = "English",
volume = "67",
pages = "1312--1315",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer Nature",
number = "7",

}

RIS

TY - JOUR

T1 - Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands

AU - Mikolaichuk, O. V.

AU - Protas, A. V.

AU - Popova, E. A.

AU - Mukhametshina, A. V.

AU - Ovsepyan, G. K.

AU - Trifonov, R. E.

N1 - Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1

PY - 2018

Y1 - 2018

N2 - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.

AB - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.

KW - DNA binding constants

KW - Pt and Pd complexes

KW - tetrazoles

KW - tetrazolylacetic acids

UR - http://www.scopus.com/inward/record.url?scp=85054192095&partnerID=8YFLogxK

U2 - 10.1007/s11172-018-2217-1

DO - 10.1007/s11172-018-2217-1

M3 - Article

VL - 67

SP - 1312

EP - 1315

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 7

ER -

ID: 35486837