Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. / Mikolaichuk, O. V. ; Protas, A. V. ; Popova, E. A. ; Mukhametshina, A. V. ; Ovsepyan, G. K. ; Trifonov, R. E. .
в: Russian Chemical Bulletin, Том 67, № 7, 2018, стр. 1312-1315.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands
AU - Mikolaichuk, O. V.
AU - Protas, A. V.
AU - Popova, E. A.
AU - Mukhametshina, A. V.
AU - Ovsepyan, G. K.
AU - Trifonov, R. E.
N1 - Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1
PY - 2018
Y1 - 2018
N2 - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.
AB - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.
KW - DNA binding constants
KW - Pt and Pd complexes
KW - tetrazoles
KW - tetrazolylacetic acids
UR - http://www.scopus.com/inward/record.url?scp=85054192095&partnerID=8YFLogxK
U2 - 10.1007/s11172-018-2217-1
DO - 10.1007/s11172-018-2217-1
M3 - Article
VL - 67
SP - 1312
EP - 1315
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 7
ER -
ID: 35486837