Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands

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Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. / Mikolaichuk, O. V. ; Protas, A. V. ; Popova, E. A. ; Mukhametshina, A. V. ; Ovsepyan, G. K. ; Trifonov, R. E. .

в: Russian Chemical Bulletin, Том 67, № 7, 2018, стр. 1312-1315.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{d76475f1715d45f385f982b0dd222af6,

title = "Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands",

abstract = "The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA. ",

keywords = "DNA binding constants, Pt and Pd complexes, tetrazoles, tetrazolylacetic acids",

author = "Mikolaichuk, {O. V.} and Protas, {A. V.} and Popova, {E. A.} and Mukhametshina, {A. V.} and Ovsepyan, {G. K.} and Trifonov, {R. E.}",

note = "Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1",

year = "2018",

doi = "10.1007/s11172-018-2217-1",

language = "English",

volume = "67",

pages = "1312--1315",

journal = "Russian Chemical Bulletin",

issn = "1066-5285",

publisher = "Springer Nature",

number = "7",

}

RIS

TY - JOUR

T1 - Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands

AU - Mikolaichuk, O. V.

AU - Protas, A. V.

AU - Popova, E. A.

AU - Mukhametshina, A. V.

AU - Ovsepyan, G. K.

AU - Trifonov, R. E.

N1 - Mikolaichuk, O.V., Protas, A.V., Popova, E.A. et al. Quantitative studies of DNA binding with trans complexes of PtII and PdII featuring tetrazolylacetic acids and their derivatives as ligands. Russ Chem Bull 67, 1312–1315 (2018). https://doi.org/10.1007/s11172-018-2217-1

PY - 2018

Y1 - 2018

N2 - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.

AB - The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.

KW - DNA binding constants

KW - Pt and Pd complexes

KW - tetrazoles

KW - tetrazolylacetic acids

UR - http://www.scopus.com/inward/record.url?scp=85054192095&partnerID=8YFLogxK

U2 - 10.1007/s11172-018-2217-1

DO - 10.1007/s11172-018-2217-1

M3 - Article

VL - 67

SP - 1312

EP - 1315

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 7

ER -

ID: 35486837