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The interaction of calf thymus DNA (CT DNA) with trans-[PtCl 2L 2] and trans-[PdCl 2L 2] complexes (L–5-methyl-1H-tetrazol-1-ylacetic acid and its ethyl, butyl, and isobutyl esters; ethyl esters of 2-R-2H-tetrazol-5-ylacetic acids, R = Bu t, CH 2CH 2OH) have been quantitatively studied by a spectrophotometric method. The binding constants (K b) of the tetrazolecontaining coordination compounds with CT DNA at pH 7.2 and 298 K are in the range of (3.67–5.93)•10 5 mol L –1 for the Pd II complexes and (7.82–13.30)•10 5 mol L –1 for and the Pt II complexes, respectively. The K b values, as well as negative values of ΔG b (–(31.7–34.9) kJ mol –1) indicate the effective binding between the studied complexes and CT DNA.

Original languageEnglish
Pages (from-to)1312-1315
Number of pages4
JournalRussian Chemical Bulletin
Volume67
Issue number7
DOIs
StatePublished - 2018

    Scopus subject areas

  • Chemistry(all)

    Research areas

  • DNA binding constants, Pt and Pd complexes, tetrazoles, tetrazolylacetic acids

ID: 35486837