The aim of this study was to investigate the functional role of the TAAR1 receptor, one of the representatives of trace amine-associated receptors (TAARs). The behavior of TAAR1-KO knockout mice and wild-type (WT) mice were studied in tests reflecting the anxiety and depressive-like conditions. In the Novelty-Suppressed Feeding test, it was shown that in TAAR1-KO mice the average time to approach the bait was significantly shorter than in WT mice. No statistically significant differences were found for all other parameters of feeding behavior (latency before the start of eating, duration of food consumption, number of approaches with sniffing the bait, number of meals). In the tail suspension test and the Porsolt forced swimming test, the LP of the first immobilization was significantly higher in TAAR1-KO mice. In the Porsolt test, TAAR1-KO mice showed a lower duration of immobilization compared to WT mice.