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Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior. / Виноградова, Екатерина Павловна; Александров, Александр Алексеевич; Козырева, Анна Владимировна; Орлова, Диана Николаевна; Беляков, Даниил Владимирович.

In: Journal of Evolutionary Biochemistry and Physiology, Vol. 61, No. 1, 03.2025, p. 241-248.

Research output: Contribution to journal › Article › peer-review

Harvard

Виноградова, ЕП, Александров, АА, Козырева, АВ, Орлова, ДН & Беляков, ДВ 2025, 'Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior', Journal of Evolutionary Biochemistry and Physiology, vol. 61, no. 1, pp. 241-248. https://doi.org/10.1134/s0022093025010193

APA

Виноградова, Е. П., Александров, А. А., Козырева, А. В., Орлова, Д. Н., & Беляков, Д. В. (2025). Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior. Journal of Evolutionary Biochemistry and Physiology, 61(1), 241-248. https://doi.org/10.1134/s0022093025010193

Vancouver

Виноградова ЕП, Александров АА, Козырева АВ, Орлова ДН, Беляков ДВ. Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior. Journal of Evolutionary Biochemistry and Physiology. 2025 Mar;61(1):241-248. https://doi.org/10.1134/s0022093025010193

Author

Виноградова, Екатерина Павловна ; Александров, Александр Алексеевич ; Козырева, Анна Владимировна ; Орлова, Диана Николаевна ; Беляков, Даниил Владимирович. / Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior. In: Journal of Evolutionary Biochemistry and Physiology. 2025 ; Vol. 61, No. 1. pp. 241-248.

BibTeX

@article{28ad42ff9cc5459a90f830d7be4aca55,
title = "Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior",
abstract = "The aim of this study was to investigate the functional role of the TAAR1 receptor, one of the representatives of trace amine-associated receptors (TAARs). The behavior of TAAR1-KO knockout mice and wild-type (WT) mice were studied in tests reflecting the anxiety and depressive-like conditions. In the Novelty-Suppressed Feeding test, it was shown that in TAAR1-KO mice the average time to approach the bait was significantly shorter than in WT mice. No statistically significant differences were found for all other parameters of feeding behavior (latency before the start of eating, duration of food consumption, number of approaches with sniffing the bait, number of meals). In the tail suspension test and the Porsolt forced swimming test, the LP of the first immobilization was significantly higher in TAAR1-KO mice. In the Porsolt test, TAAR1-KO mice showed a lower duration of immobilization compared to WT mice.",
author = "Виноградова, {Екатерина Павловна} and Александров, {Александр Алексеевич} and Козырева, {Анна Владимировна} and Орлова, {Диана Николаевна} and Беляков, {Даниил Владимирович}",
year = "2025",
month = mar,
doi = "10.1134/s0022093025010193",
language = "English",
volume = "61",
pages = "241--248",
journal = "Journal of Evolutionary Biochemistry and Physiology",
issn = "0022-0930",
publisher = "Pleiades Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of TAAR1 Knockout on Behavior Characteristics of Mice in Tests Assessing Anxiety and Depressive-Like Behavior

AU - Виноградова, Екатерина Павловна

AU - Александров, Александр Алексеевич

AU - Козырева, Анна Владимировна

AU - Орлова, Диана Николаевна

AU - Беляков, Даниил Владимирович

PY - 2025/3

Y1 - 2025/3

N2 - The aim of this study was to investigate the functional role of the TAAR1 receptor, one of the representatives of trace amine-associated receptors (TAARs). The behavior of TAAR1-KO knockout mice and wild-type (WT) mice were studied in tests reflecting the anxiety and depressive-like conditions. In the Novelty-Suppressed Feeding test, it was shown that in TAAR1-KO mice the average time to approach the bait was significantly shorter than in WT mice. No statistically significant differences were found for all other parameters of feeding behavior (latency before the start of eating, duration of food consumption, number of approaches with sniffing the bait, number of meals). In the tail suspension test and the Porsolt forced swimming test, the LP of the first immobilization was significantly higher in TAAR1-KO mice. In the Porsolt test, TAAR1-KO mice showed a lower duration of immobilization compared to WT mice.

AB - The aim of this study was to investigate the functional role of the TAAR1 receptor, one of the representatives of trace amine-associated receptors (TAARs). The behavior of TAAR1-KO knockout mice and wild-type (WT) mice were studied in tests reflecting the anxiety and depressive-like conditions. In the Novelty-Suppressed Feeding test, it was shown that in TAAR1-KO mice the average time to approach the bait was significantly shorter than in WT mice. No statistically significant differences were found for all other parameters of feeding behavior (latency before the start of eating, duration of food consumption, number of approaches with sniffing the bait, number of meals). In the tail suspension test and the Porsolt forced swimming test, the LP of the first immobilization was significantly higher in TAAR1-KO mice. In the Porsolt test, TAAR1-KO mice showed a lower duration of immobilization compared to WT mice.

U2 - 10.1134/s0022093025010193

DO - 10.1134/s0022093025010193

M3 - Article

VL - 61

SP - 241

EP - 248

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 1

ER -

ID: 132668568