It is known that heterologous protein production in microorganisms has negative influence upon a host cell. In this regard, of particular interest is to know the fate of recombinant proteins in a cell. In this study, it was shown that NLS of bovine gamma-interferon functions in yeast Pichia pastoris cells. The absence of the C-terminal NLS of bovine gamma-interferon leads to cytoplasmic localization of the recombinant protein.

Translated title of the contributionNuclear localization sequence of bovine gamma-interferon provides translocation of recombinant protein to yeast Pichia pastoris cell nucleus
Original languageRussian
Pages (from-to)863-868
Number of pages6
JournalЦитология
Volume52
Issue number10
StatePublished - 2010

    Research areas

  • Bovine gamma-interferon, Nuclear localization sequence, Recombinant proteins

    Scopus subject areas

  • Medicine(all)

ID: 5120583