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@article{42450f449af744c9b52104f36b9b12e9,
title = "СИГНАЛ ЯДЕРНОЙ ЛОКАЛИЗАЦИИ ГАММА-ИНТЕРФЕРОНА БЫКА ОБЕСПЕЧИВАЕТ ТРАНСЛОКАЦИЮ РЕКОМБИНАНТНОГО БЕЛКА В ЯДРО КЛЕТКИ ДРОЖЖЕЙ PICHIA PASTORIS",
abstract = "It is known that heterologous protein production in microorganisms has negative influence upon a host cell. In this regard, of particular interest is to know the fate of recombinant proteins in a cell. In this study, it was shown that NLS of bovine gamma-interferon functions in yeast Pichia pastoris cells. The absence of the C-terminal NLS of bovine gamma-interferon leads to cytoplasmic localization of the recombinant protein.",
keywords = "Bovine gamma-interferon, Nuclear localization sequence, Recombinant proteins",
author = "Gradoboeva, {A. E.} and Padkina, {M. V.}",
year = "2010",
language = "русский",
volume = "52",
pages = "863--868",
journal = "Цитология",
issn = "0041-3771",
publisher = "МАИК {"}Наука/Интерпериодика{"}",
number = "10",

}

RIS

TY - JOUR

T1 - СИГНАЛ ЯДЕРНОЙ ЛОКАЛИЗАЦИИ ГАММА-ИНТЕРФЕРОНА БЫКА ОБЕСПЕЧИВАЕТ ТРАНСЛОКАЦИЮ РЕКОМБИНАНТНОГО БЕЛКА В ЯДРО КЛЕТКИ ДРОЖЖЕЙ PICHIA PASTORIS

AU - Gradoboeva, A. E.

AU - Padkina, M. V.

PY - 2010

Y1 - 2010

N2 - It is known that heterologous protein production in microorganisms has negative influence upon a host cell. In this regard, of particular interest is to know the fate of recombinant proteins in a cell. In this study, it was shown that NLS of bovine gamma-interferon functions in yeast Pichia pastoris cells. The absence of the C-terminal NLS of bovine gamma-interferon leads to cytoplasmic localization of the recombinant protein.

AB - It is known that heterologous protein production in microorganisms has negative influence upon a host cell. In this regard, of particular interest is to know the fate of recombinant proteins in a cell. In this study, it was shown that NLS of bovine gamma-interferon functions in yeast Pichia pastoris cells. The absence of the C-terminal NLS of bovine gamma-interferon leads to cytoplasmic localization of the recombinant protein.

KW - Bovine gamma-interferon

KW - Nuclear localization sequence

KW - Recombinant proteins

UR - http://www.scopus.com/inward/record.url?scp=79952257362&partnerID=8YFLogxK

M3 - статья

C2 - 21268843

VL - 52

SP - 863

EP - 868

JO - Цитология

JF - Цитология

SN - 0041-3771

IS - 10

ER -

ID: 5120583