The goal of the study was to identify the features of speech of children with autism spectrum disorders (ASD) depending on their physiological and psychophysiological characteristics correlated with speech activity in comparison with typically developing (TD) peers. Participants in the study were children with ASD (F84 inICD-10) aged 5-16 years (n = 40) and their TD peers (n = = 300). On the basis of the analysis of physiological parameters of children at the birth, psychophysiological characteristics and level of speech formation, direct and indirect connections that influence on the formation of speech of TD children and children with ASD, what indicating about a complex unequal development trajectory, are revealed. The study is a part of the complex investigation of speech ontogenesis in typically and atypically child's development.