Background. Colorectal cancer (CRC) makes up a significant share in the overall structure of cancer, and mortality from it remains high. Patients with colon polyps have an increased risk of colorectal cancer and should be closely monitored. However, even when all criteria for a high-quality colonoscopy are met, the prevalence of interval colorectal cancer (iCRC) remains significant. Objective. The aim of our study was to determine the incidence of iCRC depending on the number and size of colon polyps. In ad-dition, we evaluated the dynamics of recurrent colorectal polyps. Materials and Methods. A retrospective multicenter cohort study enrolled 733 patients with colon polyps between 2002 and 2020. The data on the patterns of detection of recurrent colorectal polyps and iCRC were evaluated and statistically processed. Results. Between 2002 and 2020, 733 patients underwent 3240 colonoscopy. Recurrent colon polyps were found in 86% of pa-tients. In patients with primary large polyps, other large polyps were again detected 4.5 times more often than in patients with small polyps. In 14% of patients with previously identified polyps less than 1 cm, newly formed polyps larger than 1 cm were en-countered. 16 cases of colorectal adenocarcinoma were identified, which amounted to 2.1% of the total sample. In 13 patients (81%), the surveillance interval corresponded to the recommended one. Conclusion. The majority of patients with colon polyps had recurrent polyps. Patients with both large and small polyps are at risk of iCRC, however, patients with large polyps are 6 times more likely to have ICRC.