TY - JOUR

T1 - Vliianie taurina na sviazyvanie 45Ca2+ mikrosomal'nymi membranami kletok golovnogo mozga

AU - Gurevich, V S

AU - Denisenko, A D

AU - Kulikova, O G

AU - Konoshenko, N V

PY - 1979/9/1

Y1 - 1979/9/1

N2 - Effect of taurine o binding of 45Ca2+ and 8-aniline-I-naphthaline culfonate by microsomes of rat brain cells was studied. Increased accumulation of Ca2+ in phospholipids of microsomes as well as a distinct decrease in the number of sites for binding of 8-aniline-I-naphthaline sulfonate were observed in presence of taurine. Activity of Ca2+-ATPase was simultaneously increased. The data obtained suggest that the effect of taurine on biomembranes is related to local alterations in their surface charge.

AB - Effect of taurine o binding of 45Ca2+ and 8-aniline-I-naphthaline culfonate by microsomes of rat brain cells was studied. Increased accumulation of Ca2+ in phospholipids of microsomes as well as a distinct decrease in the number of sites for binding of 8-aniline-I-naphthaline sulfonate were observed in presence of taurine. Activity of Ca2+-ATPase was simultaneously increased. The data obtained suggest that the effect of taurine on biomembranes is related to local alterations in their surface charge.

KW - Anilino Naphthalenesulfonates/metabolism

KW - Animals

KW - Brain/metabolism

KW - Calcium/metabolism

KW - Calcium Radioisotopes

KW - Cations, Divalent

KW - Cell Membrane/drug effects

KW - Endoplasmic Reticulum/metabolism

KW - Microsomes/drug effects

KW - Protein Binding/drug effects

KW - Rats

KW - Taurine/pharmacology

M3 - статья

C2 - 494540

VL - 25

SP - 565

EP - 568

JO - БИОМЕДИЦИНСКАЯ ХИМИЯ

JF - БИОМЕДИЦИНСКАЯ ХИМИЯ

SN - 2310-6905

IS - 5

ER -