TY - JOUR

T1 - Vimentin as antigenic target in autoimmunity

T2 - A comprehensive review

AU - Musaelyan, Aram

AU - Lapin, Sergey

AU - Nazarov, Vladimir

AU - Tkachenko, Olga

AU - Gilburd, Boris

AU - Mazing, Alexandra

AU - Mikhailova, Lilia

AU - Shoenfeld, Yehuda

N1 - Copyright © 2018. Published by Elsevier B.V.

PY - 2018/9

Y1 - 2018/9

N2 - Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.

AB - Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.

KW - Arthritis, Rheumatoid/immunology

KW - Autoimmunity/drug effects

KW - Humans

KW - Lupus Erythematosus, Systemic/immunology

KW - Protein Processing, Post-Translational/genetics

KW - Vimentin/immunology

KW - Vimentin

KW - Post-translational modifications

KW - Systemic lupus erythematosus

KW - Sarcoidosis

KW - Rheumatoid arthritis

KW - Autoimmune diseases

KW - RHEUMATOID-ARTHRITIS

KW - CITRULLINATED PEPTIDE ANTIBODY

KW - ANKYLOSING-SPONDYLITIS

KW - HLA-DRB1 SHARED EPITOPE

KW - ANTIPHOSPHOLIPID SYNDROME

KW - FILAMENT PROTEIN VIMENTIN

KW - HUMAN LUPUS NEPHRITIS

KW - MMP-DEGRADED VIMENTIN

KW - IDIOPATHIC PULMONARY-FIBROSIS

KW - INTERMEDIATE-FILAMENTS

UR - http://www.scopus.com/inward/record.url?scp=85049906446&partnerID=8YFLogxK

UR - http://www.mendeley.com/research/vimentin-antigenic-target-autoimmunity-comprehensive-review

U2 - 10.1016/j.autrev.2018.04.004

DO - 10.1016/j.autrev.2018.04.004

M3 - Review article

C2 - 30009963

VL - 17

SP - 926

EP - 934

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 9

ER -