Vimentin as antigenic target in autoimmunity : A comprehensive review. / Musaelyan, Aram; Lapin, Sergey; Nazarov, Vladimir; Tkachenko, Olga; Gilburd, Boris; Mazing, Alexandra; Mikhailova, Lilia; Shoenfeld, Yehuda.
In: Autoimmunity Reviews, Vol. 17, No. 9, 09.2018, p. 926-934.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Vimentin as antigenic target in autoimmunity
T2 - A comprehensive review
AU - Musaelyan, Aram
AU - Lapin, Sergey
AU - Nazarov, Vladimir
AU - Tkachenko, Olga
AU - Gilburd, Boris
AU - Mazing, Alexandra
AU - Mikhailova, Lilia
AU - Shoenfeld, Yehuda
N1 - Copyright © 2018. Published by Elsevier B.V.
PY - 2018/9
Y1 - 2018/9
N2 - Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.
AB - Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Vimentin plays a key role in the physiology of the cell, cellular interactions and the functioning of the immune system. Post-translationally modified and native forms of vimentin are involved in the pathogenesis of inflammation and many autoimmune diseases: rheumatoid arthritis, sarcoidosis, systemic lupus erythematosus, antiphospholipid syndrome, Crohn's disease, ankylosing spondyloarthritis and idiopathic pulmonary fibrosis. Modifications of the protein lead to the formation of antigenic epitopes and, as a result, to the synthesis of antibodies. Citrullinated, carbamylated and acetylated forms of vimentin participate in the pathogenesis of RA, and antibodies against them serve as diagnostic and prognostic markers of the disease. Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis. In addition, vimentin takes part in pathogenesis of tubulointerstitial inflammation and glomerulonephritis in lupus. In antiphospholipid syndrome interactions of vimentin and cardiolipin on the surface of apoptotic cells lead to the formation of an immunogenic complex. Antibodies against vimentin/cardiolipin complex are involved in the mechanism of thrombogenesis and serve to identify patients seronegative for antibodies to cardiolipin and ß2glycoprotein-I with the clinical features. Post-translationally modified form of the protein is citrullinated and MMP-degraded vimentin, which was found in serum of patients with Crohn's disease and ankylosing spondyloarthritis.
KW - Arthritis, Rheumatoid/immunology
KW - Autoimmunity/drug effects
KW - Humans
KW - Lupus Erythematosus, Systemic/immunology
KW - Protein Processing, Post-Translational/genetics
KW - Vimentin/immunology
KW - Vimentin
KW - Post-translational modifications
KW - Systemic lupus erythematosus
KW - Sarcoidosis
KW - Rheumatoid arthritis
KW - Autoimmune diseases
KW - RHEUMATOID-ARTHRITIS
KW - CITRULLINATED PEPTIDE ANTIBODY
KW - ANKYLOSING-SPONDYLITIS
KW - HLA-DRB1 SHARED EPITOPE
KW - ANTIPHOSPHOLIPID SYNDROME
KW - FILAMENT PROTEIN VIMENTIN
KW - HUMAN LUPUS NEPHRITIS
KW - MMP-DEGRADED VIMENTIN
KW - IDIOPATHIC PULMONARY-FIBROSIS
KW - INTERMEDIATE-FILAMENTS
UR - http://www.scopus.com/inward/record.url?scp=85049906446&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/vimentin-antigenic-target-autoimmunity-comprehensive-review
U2 - 10.1016/j.autrev.2018.04.004
DO - 10.1016/j.autrev.2018.04.004
M3 - Review article
C2 - 30009963
VL - 17
SP - 926
EP - 934
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 9
ER -
ID: 36172039