Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. / Dominici, Nadia; Keller, Urs; Vallery, Heike; Friedli, Lucia; Van Den Brand, Rubia; Starkey, Michelle L.; Musienko, Pavel; Riener, Robert; Courtine, Grégoire.
в: Nature Medicine, Том 18, № 7, 01.07.2012, стр. 1142-1147.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders
AU - Dominici, Nadia
AU - Keller, Urs
AU - Vallery, Heike
AU - Friedli, Lucia
AU - Van Den Brand, Rubia
AU - Starkey, Michelle L.
AU - Musienko, Pavel
AU - Riener, Robert
AU - Courtine, Grégoire
PY - 2012/7/1
Y1 - 2012/7/1
N2 - Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.
AB - Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.
UR - http://www.scopus.com/inward/record.url?scp=84863718270&partnerID=8YFLogxK
U2 - 10.1038/nm.2845
DO - 10.1038/nm.2845
M3 - Article
C2 - 22653117
VL - 18
SP - 1142
EP - 1147
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 7
ER -
ID: 5574110