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Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. / Dominici, Nadia; Keller, Urs; Vallery, Heike; Friedli, Lucia; Van Den Brand, Rubia; Starkey, Michelle L.; Musienko, Pavel; Riener, Robert; Courtine, Grégoire.

In: Nature Medicine, Vol. 18, No. 7, 01.07.2012, p. 1142-1147.

Research output: Contribution to journal › Article › peer-review

Harvard

Dominici, N, Keller, U, Vallery, H, Friedli, L, Van Den Brand, R, Starkey, ML, Musienko, P, Riener, R & Courtine, G 2012, 'Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders', Nature Medicine, vol. 18, no. 7, pp. 1142-1147. https://doi.org/10.1038/nm.2845

APA

Dominici, N., Keller, U., Vallery, H., Friedli, L., Van Den Brand, R., Starkey, M. L., Musienko, P., Riener, R., & Courtine, G. (2012). Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. Nature Medicine, 18(7), 1142-1147. https://doi.org/10.1038/nm.2845

Vancouver

Dominici N, Keller U, Vallery H, Friedli L, Van Den Brand R, Starkey ML et al. Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. Nature Medicine. 2012 Jul 1;18(7):1142-1147. https://doi.org/10.1038/nm.2845

Author

Dominici, Nadia ; Keller, Urs ; Vallery, Heike ; Friedli, Lucia ; Van Den Brand, Rubia ; Starkey, Michelle L. ; Musienko, Pavel ; Riener, Robert ; Courtine, Grégoire. / Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders. In: Nature Medicine. 2012 ; Vol. 18, No. 7. pp. 1142-1147.

BibTeX

@article{c94d2edce2024c069c15654c73b464af,
title = "Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders",
abstract = "Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.",
author = "Nadia Dominici and Urs Keller and Heike Vallery and Lucia Friedli and {Van Den Brand}, Rubia and Starkey, {Michelle L.} and Pavel Musienko and Robert Riener and Gr{\'e}goire Courtine",
year = "2012",
month = jul,
day = "1",
doi = "10.1038/nm.2845",
language = "English",
volume = "18",
pages = "1142--1147",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

AU - Dominici, Nadia

AU - Keller, Urs

AU - Vallery, Heike

AU - Friedli, Lucia

AU - Van Den Brand, Rubia

AU - Starkey, Michelle L.

AU - Musienko, Pavel

AU - Riener, Robert

AU - Courtine, Grégoire

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.

AB - Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluate, enable and train pattern generation and balance independently during natural walking behaviors in rats. In evaluation mode, the robotic interface affords detailed assessments of pattern generation and dynamic equilibrium after spinal cord injury (SCI) and stroke. In enabling mode, the robot acts as a propulsive or postural neuroprosthesis that instantly promotes unexpected locomotor capacities including overground walking after complete SCI, stair climbing following partial SCI and precise paw placement shortly after stroke. In training mode, robot-enabled rehabilitation, epidural electrical stimulation and monoamine agonists reestablish weight-supported locomotion, coordinated steering and balance in rats with a paralyzing SCI. This new robotic technology and associated concepts have broad implications for both assessing and restoring motor functions after CNS disorders, both in animals and in humans.

UR - http://www.scopus.com/inward/record.url?scp=84863718270&partnerID=8YFLogxK

U2 - 10.1038/nm.2845

DO - 10.1038/nm.2845

M3 - Article

C2 - 22653117

VL - 18

SP - 1142

EP - 1147

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 7

ER -

ID: 5574110