Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents

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Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. / Deyoung, Colin G.; Getchell, Marya; Koposov, Roman A.; Yrigollen, Carolyn M.; Haeffel, Gerald J.; Klinteberg, Britt Af; Oreland, Lars; Ruchkin, Vladislav V.; Pakstis, Andrew J.; Grigorenko, Elena L.

в: Psychiatric Genetics, Том 20, № 1, 02.2010, стр. 20-24.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Deyoung, Colin G. ; Getchell, Marya ; Koposov, Roman A. ; Yrigollen, Carolyn M. ; Haeffel, Gerald J. ; Klinteberg, Britt Af ; Oreland, Lars ; Ruchkin, Vladislav V. ; Pakstis, Andrew J. ; Grigorenko, Elena L. / Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents. в: Psychiatric Genetics. 2010 ; Том 20, № 1. стр. 20-24.

BibTeX

@article{d34a3a0008224873a0237634424c9e53,

title = "Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents",

abstract = "Objective: Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method: This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results: The Val allele of the ValMet polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion: The ValMet polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.",

keywords = "Antisocial behavior, Attention deficit/hyperactivity disorder, Catechol-O-methyltransferase, Conduct disorder, Genetics",

author = "Deyoung, {Colin G.} and Marya Getchell and Koposov, {Roman A.} and Yrigollen, {Carolyn M.} and Haeffel, {Gerald J.} and Klinteberg, {Britt Af} and Lars Oreland and Ruchkin, {Vladislav V.} and Pakstis, {Andrew J.} and Grigorenko, {Elena L.}",

year = "2010",

month = feb,

doi = "10.1097/YPG.0b013e32833511e4",

language = "English",

volume = "20",

pages = "20--24",

journal = "Psychiatric Genetics",

issn = "0955-8829",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

RIS

TY - JOUR

T1 - Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents

AU - Deyoung, Colin G.

AU - Getchell, Marya

AU - Koposov, Roman A.

AU - Yrigollen, Carolyn M.

AU - Haeffel, Gerald J.

AU - Klinteberg, Britt Af

AU - Oreland, Lars

AU - Ruchkin, Vladislav V.

AU - Pakstis, Andrew J.

AU - Grigorenko, Elena L.

PY - 2010/2

Y1 - 2010/2

N2 - Objective: Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method: This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results: The Val allele of the ValMet polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion: The ValMet polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.

AB - Objective: Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined. Method: This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents. Results: The Val allele of the ValMet polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms. Conclusion: The ValMet polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.

KW - Antisocial behavior

KW - Attention deficit/hyperactivity disorder

KW - Catechol-O-methyltransferase

KW - Conduct disorder

KW - Genetics

UR - http://www.scopus.com/inward/record.url?scp=75149138337&partnerID=8YFLogxK

U2 - 10.1097/YPG.0b013e32833511e4

DO - 10.1097/YPG.0b013e32833511e4

M3 - Article

C2 - 19997043

AN - SCOPUS:75149138337

VL - 20

SP - 20

EP - 24

JO - Psychiatric Genetics

JF - Psychiatric Genetics

SN - 0955-8829

IS - 1

ER -

ID: 87389777