Результаты исследований: Научные публикации в периодических изданиях › статья в журнале по материалам конференции › Рецензирование
Interaction of native calf thymus DNA (ctDNA) with phenacylimidazo[5,1- a]isoquinoline derivatives was studied by the methods of spectrophotometry, viscometry, isothermal titration calorimetry (ITC) and dynamic birefringence. It was found that both of investigated compounds form complexes with the DNA molecule, the structure of compounds affects the mode of binding these ligands to DNA. The primary binding mode can not be described by the classical models of groove binding or intercalation. It has been suggested that the primary mode of binding is partial intercalation.
Язык оригинала | английский |
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Номер статьи | 012020 |
Журнал | Journal of Physics: Conference Series |
Том | 661 |
Номер выпуска | 1 |
DOI | |
Состояние | Опубликовано - 2 дек 2015 |
Событие | 17th Russian Youth Conference on Physics and Astronomy, PhysicA.SPb 2014 - St. Petersburg, Российская Федерация Продолжительность: 28 окт 2014 → 30 окт 2014 |
ID: 100855380