The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes

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The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes. / Чихиржина, Елена Всеволодовна; Старкова , Татьяна Юрьевна; Поляничко, Александр Михайлович.

в: Biophysics, Том 66, № 3, 05.2021, стр. 373-378.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{6772f9423f334e6d90ba584e9b5861fd,

title = "The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes",

abstract = "HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.",

keywords = "DNA, Keywords: HMGB1 protein, chromatin structure, histone H1",

author = "Чихиржина, {Елена Всеволодовна} and Старкова, {Татьяна Юрьевна} and Поляничко, {Александр Михайлович}",

note = "Publisher Copyright: {\textcopyright} 2021, Pleiades Publishing, Inc.",

year = "2021",

month = may,

doi = "10.1134/s0006350921030039",

language = "English",

volume = "66",

pages = "373--378",

journal = "Biophysics (Russian Federation)",

issn = "0006-3509",

publisher = "Springer Nature",

number = "3",

}

RIS

TY - JOUR

T1 - The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes

AU - Чихиржина, Елена Всеволодовна

AU - Старкова , Татьяна Юрьевна

AU - Поляничко, Александр Михайлович

PY - 2021/5

Y1 - 2021/5

N2 - HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.

AB - HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.

KW - DNA

KW - Keywords: HMGB1 protein

KW - chromatin structure

KW - histone H1

UR - http://www.scopus.com/inward/record.url?scp=85113688667&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/4fa8321c-36ca-3b21-974b-7950af272e8e/

U2 - 10.1134/s0006350921030039

DO - 10.1134/s0006350921030039

M3 - Article

VL - 66

SP - 373

EP - 378

JO - Biophysics (Russian Federation)

JF - Biophysics (Russian Federation)

SN - 0006-3509

IS - 3

ER -

ID: 85793253