Research output: Contribution to journal › Article › peer-review
The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes. / Чихиржина, Елена Всеволодовна; Старкова , Татьяна Юрьевна; Поляничко, Александр Михайлович.
In: Biophysics, Vol. 66, No. 3, 05.2021, p. 373-378.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - The structural organization of the HMGB1 nuclear protein and its effect on the formation of ordered supramolecular complexes
AU - Чихиржина, Елена Всеволодовна
AU - Старкова , Татьяна Юрьевна
AU - Поляничко, Александр Михайлович
N1 - Publisher Copyright: © 2021, Pleiades Publishing, Inc.
PY - 2021/5
Y1 - 2021/5
N2 - HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.
AB - HMGB1 is one of the key proteins of the cell. HMGB1 performs its main functions predominantly in the cell nucleus, as an essential component of DNA–protein and multiprotein complexes. It plays an important role in various cellular processes, such as transcription, replication, and DNA repair. However, it has also been found outside the nucleus: in the cytoplasmic and extracellular space. Despite numerous publications on the structure and functioning of HMGB1, the molecular mechanisms that underlie the vast variety of functions performed by this protein still remain unclear. In this paper, we report recent data on the organization of the protein structure and its effects on HMGB1 interactions with DNA and other proteins.
KW - DNA
KW - Keywords: HMGB1 protein
KW - chromatin structure
KW - histone H1
UR - http://www.scopus.com/inward/record.url?scp=85113688667&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/4fa8321c-36ca-3b21-974b-7950af272e8e/
U2 - 10.1134/s0006350921030039
DO - 10.1134/s0006350921030039
M3 - Article
VL - 66
SP - 373
EP - 378
JO - Biophysics (Russian Federation)
JF - Biophysics (Russian Federation)
SN - 0006-3509
IS - 3
ER -
ID: 85793253