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The melatonergic pathway and its interactions in modulating respiratory system disorders. / Mazzoccoli, Gianluigi; Kvetnoy, Igor; Mironova, Ekaterina; Yablonskiy, Petr; Sokolovich, Evgenii; Krylova, Julia; Carbone, Annalucia; Anderson, George; Polyakova, Victoria.

в: Biomedicine and Pharmacotherapy, Том 137, 111397, 01.05.2021.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Mazzoccoli, G, Kvetnoy, I, Mironova, E, Yablonskiy, P, Sokolovich, E, Krylova, J, Carbone, A, Anderson, G & Polyakova, V 2021, 'The melatonergic pathway and its interactions in modulating respiratory system disorders', Biomedicine and Pharmacotherapy, Том. 137, 111397. https://doi.org/10.1016/j.biopha.2021.111397, https://doi.org/10.1016/j.biopha.2021.111397

APA

Mazzoccoli, G., Kvetnoy, I., Mironova, E., Yablonskiy, P., Sokolovich, E., Krylova, J., Carbone, A., Anderson, G., & Polyakova, V. (2021). The melatonergic pathway and its interactions in modulating respiratory system disorders. Biomedicine and Pharmacotherapy, 137, [111397]. https://doi.org/10.1016/j.biopha.2021.111397, https://doi.org/10.1016/j.biopha.2021.111397

Vancouver

Mazzoccoli G, Kvetnoy I, Mironova E, Yablonskiy P, Sokolovich E, Krylova J и пр. The melatonergic pathway and its interactions in modulating respiratory system disorders. Biomedicine and Pharmacotherapy. 2021 Май 1;137. 111397. https://doi.org/10.1016/j.biopha.2021.111397, https://doi.org/10.1016/j.biopha.2021.111397

Author

Mazzoccoli, Gianluigi ; Kvetnoy, Igor ; Mironova, Ekaterina ; Yablonskiy, Petr ; Sokolovich, Evgenii ; Krylova, Julia ; Carbone, Annalucia ; Anderson, George ; Polyakova, Victoria. / The melatonergic pathway and its interactions in modulating respiratory system disorders. в: Biomedicine and Pharmacotherapy. 2021 ; Том 137.

BibTeX

@article{23d4f9cf3c8c44779baa68c4f3f6bcd0,
title = "The melatonergic pathway and its interactions in modulating respiratory system disorders",
abstract = "Melatonin is a key intracellular neuroimmune-endocrine regulator and coordinator of multiple complex and interrelated biological processes. The main functions of melatonin include the regulation of neuroendocrine and antioxidant system activity, blood pressure, rhythms of the sleep-wake cycle, the retardation of ageing processes, as well as reseting and optimizing mitochondria and thereby the cells of the immune system. Melatonin and its agonists have therefore been mooted as a treatment option across a wide array of medical disorders. This article reviews the role of melatonin in the regulation of respiratory system functions under normal and pathological conditions. Melatonin can normalize the structural and functional organization of damaged lung tissues, by a number of mechanisms, including the regulation of signaling molecules, oxidant status, lipid raft function, optimized mitochondrial function and reseting of the immune response over the circadian rhythm. Consequently, melatonin has potential clinical utility for bronchial asthma, chronic obstructive pulmonary disease, lung cancer, lung vascular diseases, as well as pulmonary and viral infections. The integration of melatonin's effects with the alpha 7 nicotinic receptor and the aryl hydrocarbon receptor in the regulation of mitochondrial function are proposed as a wider framework for understanding the role of melatonin across a wide array of diverse pulmonary disorders.",
keywords = "Мелатонин Дыхательная система Сигнальные молекулы Нейроиммуноэндокринология Рецептор арилуглеводородов Альфа-7 никотиновый рецептор Митохондрии Старение Лечение, Ageing, Alpha 7 nicotinic receptor, Aryl hydrocarbon receptor, Melatonin, Mitochondria, Neuroimmunoendocrinology, Respiratory system, Signaling molecules, TreatmentNot applicable",
author = "Gianluigi Mazzoccoli and Igor Kvetnoy and Ekaterina Mironova and Petr Yablonskiy and Evgenii Sokolovich and Julia Krylova and Annalucia Carbone and George Anderson and Victoria Polyakova",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = may,
day = "1",
doi = "10.1016/j.biopha.2021.111397",
language = "English",
volume = "137",
journal = "Biomedicine and Pharmacotherapy",
issn = "0753-3322",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The melatonergic pathway and its interactions in modulating respiratory system disorders

AU - Mazzoccoli, Gianluigi

AU - Kvetnoy, Igor

AU - Mironova, Ekaterina

AU - Yablonskiy, Petr

AU - Sokolovich, Evgenii

AU - Krylova, Julia

AU - Carbone, Annalucia

AU - Anderson, George

AU - Polyakova, Victoria

N1 - Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5/1

Y1 - 2021/5/1

N2 - Melatonin is a key intracellular neuroimmune-endocrine regulator and coordinator of multiple complex and interrelated biological processes. The main functions of melatonin include the regulation of neuroendocrine and antioxidant system activity, blood pressure, rhythms of the sleep-wake cycle, the retardation of ageing processes, as well as reseting and optimizing mitochondria and thereby the cells of the immune system. Melatonin and its agonists have therefore been mooted as a treatment option across a wide array of medical disorders. This article reviews the role of melatonin in the regulation of respiratory system functions under normal and pathological conditions. Melatonin can normalize the structural and functional organization of damaged lung tissues, by a number of mechanisms, including the regulation of signaling molecules, oxidant status, lipid raft function, optimized mitochondrial function and reseting of the immune response over the circadian rhythm. Consequently, melatonin has potential clinical utility for bronchial asthma, chronic obstructive pulmonary disease, lung cancer, lung vascular diseases, as well as pulmonary and viral infections. The integration of melatonin's effects with the alpha 7 nicotinic receptor and the aryl hydrocarbon receptor in the regulation of mitochondrial function are proposed as a wider framework for understanding the role of melatonin across a wide array of diverse pulmonary disorders.

AB - Melatonin is a key intracellular neuroimmune-endocrine regulator and coordinator of multiple complex and interrelated biological processes. The main functions of melatonin include the regulation of neuroendocrine and antioxidant system activity, blood pressure, rhythms of the sleep-wake cycle, the retardation of ageing processes, as well as reseting and optimizing mitochondria and thereby the cells of the immune system. Melatonin and its agonists have therefore been mooted as a treatment option across a wide array of medical disorders. This article reviews the role of melatonin in the regulation of respiratory system functions under normal and pathological conditions. Melatonin can normalize the structural and functional organization of damaged lung tissues, by a number of mechanisms, including the regulation of signaling molecules, oxidant status, lipid raft function, optimized mitochondrial function and reseting of the immune response over the circadian rhythm. Consequently, melatonin has potential clinical utility for bronchial asthma, chronic obstructive pulmonary disease, lung cancer, lung vascular diseases, as well as pulmonary and viral infections. The integration of melatonin's effects with the alpha 7 nicotinic receptor and the aryl hydrocarbon receptor in the regulation of mitochondrial function are proposed as a wider framework for understanding the role of melatonin across a wide array of diverse pulmonary disorders.

KW - Мелатонин Дыхательная система Сигнальные молекулы Нейроиммуноэндокринология Рецептор арилуглеводородов Альфа-7 никотиновый рецептор Митохондрии Старение Лечение

KW - Ageing

KW - Alpha 7 nicotinic receptor

KW - Aryl hydrocarbon receptor

KW - Melatonin

KW - Mitochondria

KW - Neuroimmunoendocrinology

KW - Respiratory system

KW - Signaling molecules

KW - TreatmentNot applicable

UR - http://www.scopus.com/inward/record.url?scp=85101102318&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/75b2ecb2-25d4-3054-b967-46537f37da22/

U2 - 10.1016/j.biopha.2021.111397

DO - 10.1016/j.biopha.2021.111397

M3 - Review article

C2 - 33761613

VL - 137

JO - Biomedicine and Pharmacotherapy

JF - Biomedicine and Pharmacotherapy

SN - 0753-3322

M1 - 111397

ER -

ID: 74109478