Research output: Contribution to journal › Review article › peer-review
The melatonergic pathway and its interactions in modulating respiratory system disorders. / Mazzoccoli, Gianluigi; Kvetnoy, Igor; Mironova, Ekaterina; Yablonskiy, Petr; Sokolovich, Evgenii; Krylova, Julia; Carbone, Annalucia; Anderson, George; Polyakova, Victoria.
In: Biomedicine and Pharmacotherapy, Vol. 137, 111397, 01.05.2021.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - The melatonergic pathway and its interactions in modulating respiratory system disorders
AU - Mazzoccoli, Gianluigi
AU - Kvetnoy, Igor
AU - Mironova, Ekaterina
AU - Yablonskiy, Petr
AU - Sokolovich, Evgenii
AU - Krylova, Julia
AU - Carbone, Annalucia
AU - Anderson, George
AU - Polyakova, Victoria
N1 - Publisher Copyright: © 2021 The Authors Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Melatonin is a key intracellular neuroimmune-endocrine regulator and coordinator of multiple complex and interrelated biological processes. The main functions of melatonin include the regulation of neuroendocrine and antioxidant system activity, blood pressure, rhythms of the sleep-wake cycle, the retardation of ageing processes, as well as reseting and optimizing mitochondria and thereby the cells of the immune system. Melatonin and its agonists have therefore been mooted as a treatment option across a wide array of medical disorders. This article reviews the role of melatonin in the regulation of respiratory system functions under normal and pathological conditions. Melatonin can normalize the structural and functional organization of damaged lung tissues, by a number of mechanisms, including the regulation of signaling molecules, oxidant status, lipid raft function, optimized mitochondrial function and reseting of the immune response over the circadian rhythm. Consequently, melatonin has potential clinical utility for bronchial asthma, chronic obstructive pulmonary disease, lung cancer, lung vascular diseases, as well as pulmonary and viral infections. The integration of melatonin's effects with the alpha 7 nicotinic receptor and the aryl hydrocarbon receptor in the regulation of mitochondrial function are proposed as a wider framework for understanding the role of melatonin across a wide array of diverse pulmonary disorders.
AB - Melatonin is a key intracellular neuroimmune-endocrine regulator and coordinator of multiple complex and interrelated biological processes. The main functions of melatonin include the regulation of neuroendocrine and antioxidant system activity, blood pressure, rhythms of the sleep-wake cycle, the retardation of ageing processes, as well as reseting and optimizing mitochondria and thereby the cells of the immune system. Melatonin and its agonists have therefore been mooted as a treatment option across a wide array of medical disorders. This article reviews the role of melatonin in the regulation of respiratory system functions under normal and pathological conditions. Melatonin can normalize the structural and functional organization of damaged lung tissues, by a number of mechanisms, including the regulation of signaling molecules, oxidant status, lipid raft function, optimized mitochondrial function and reseting of the immune response over the circadian rhythm. Consequently, melatonin has potential clinical utility for bronchial asthma, chronic obstructive pulmonary disease, lung cancer, lung vascular diseases, as well as pulmonary and viral infections. The integration of melatonin's effects with the alpha 7 nicotinic receptor and the aryl hydrocarbon receptor in the regulation of mitochondrial function are proposed as a wider framework for understanding the role of melatonin across a wide array of diverse pulmonary disorders.
KW - Мелатонин Дыхательная система Сигнальные молекулы Нейроиммуноэндокринология Рецептор арилуглеводородов Альфа-7 никотиновый рецептор Митохондрии Старение Лечение
KW - Ageing
KW - Alpha 7 nicotinic receptor
KW - Aryl hydrocarbon receptor
KW - Melatonin
KW - Mitochondria
KW - Neuroimmunoendocrinology
KW - Respiratory system
KW - Signaling molecules
KW - TreatmentNot applicable
UR - http://www.scopus.com/inward/record.url?scp=85101102318&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/75b2ecb2-25d4-3054-b967-46537f37da22/
U2 - 10.1016/j.biopha.2021.111397
DO - 10.1016/j.biopha.2021.111397
M3 - Review article
C2 - 33761613
VL - 137
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
SN - 0753-3322
M1 - 111397
ER -
ID: 74109478