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α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? / Brodin, Lennart; Milovanovic, Dragomir; Rizzoli, Silvio; Шупляков, Олег Викторович.

в: Frontiers in Molecular Biosciences, Том 9, 891508, 18.05.2022.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Brodin, L, Milovanovic, D, Rizzoli, S & Шупляков, ОВ 2022, 'α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?', Frontiers in Molecular Biosciences, Том. 9, 891508. https://doi.org/10.3389/fmolb.2022.891508

APA

Brodin, L., Milovanovic, D., Rizzoli, S., & Шупляков, О. В. (2022). α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? Frontiers in Molecular Biosciences, 9, [891508]. https://doi.org/10.3389/fmolb.2022.891508

Vancouver

Brodin L, Milovanovic D, Rizzoli S, Шупляков ОВ. α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? Frontiers in Molecular Biosciences. 2022 Май 18;9. 891508. https://doi.org/10.3389/fmolb.2022.891508

Author

Brodin, Lennart ; Milovanovic, Dragomir ; Rizzoli, Silvio ; Шупляков, Олег Викторович. / α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?. в: Frontiers in Molecular Biosciences. 2022 ; Том 9.

BibTeX

@article{56b3d3d2161045aba690db67428e88d4,
title = "α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?",
abstract = "The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.",
keywords = "liquid-liquid phase separation (LLPS), synapse, synapsin, synaptic vesicle, synaptic vesicle clustering, α-Synuclein",
author = "Lennart Brodin and Dragomir Milovanovic and Silvio Rizzoli and Шупляков, {Олег Викторович}",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 Brodin, Milovanovic, Rizzoli and Shupliakov.",
year = "2022",
month = may,
day = "18",
doi = "10.3389/fmolb.2022.891508",
language = "English",
volume = "9",
journal = "Frontiers in Molecular Biosciences",
issn = "2296-889X",
publisher = "Frontiers Media S.A.",

}

RIS

TY - JOUR

T1 - α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

AU - Brodin, Lennart

AU - Milovanovic, Dragomir

AU - Rizzoli, Silvio

AU - Шупляков, Олег Викторович

N1 - Publisher Copyright: Copyright © 2022 Brodin, Milovanovic, Rizzoli and Shupliakov.

PY - 2022/5/18

Y1 - 2022/5/18

N2 - The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.

AB - The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.

KW - liquid-liquid phase separation (LLPS)

KW - synapse

KW - synapsin

KW - synaptic vesicle

KW - synaptic vesicle clustering

KW - α-Synuclein

UR - https://www.mendeley.com/catalogue/1cd68186-2363-39cd-a771-458a5243bf6d/

UR - http://www.scopus.com/inward/record.url?scp=85131559588&partnerID=8YFLogxK

U2 - 10.3389/fmolb.2022.891508

DO - 10.3389/fmolb.2022.891508

M3 - Review article

C2 - 35664678

VL - 9

JO - Frontiers in Molecular Biosciences

JF - Frontiers in Molecular Biosciences

SN - 2296-889X

M1 - 891508

ER -

ID: 95037162