Research output: Contribution to journal › Review article › peer-review
α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? / Brodin, Lennart; Milovanovic, Dragomir; Rizzoli, Silvio; Шупляков, Олег Викторович.
In: Frontiers in Molecular Biosciences, Vol. 9, 891508, 18.05.2022.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
AU - Brodin, Lennart
AU - Milovanovic, Dragomir
AU - Rizzoli, Silvio
AU - Шупляков, Олег Викторович
N1 - Publisher Copyright: Copyright © 2022 Brodin, Milovanovic, Rizzoli and Shupliakov.
PY - 2022/5/18
Y1 - 2022/5/18
N2 - The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.
AB - The protein α-synuclein, which is well-known for its links to Parkinson's Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.
KW - liquid-liquid phase separation (LLPS)
KW - synapse
KW - synapsin
KW - synaptic vesicle
KW - synaptic vesicle clustering
KW - α-Synuclein
UR - https://www.mendeley.com/catalogue/1cd68186-2363-39cd-a771-458a5243bf6d/
UR - http://www.scopus.com/inward/record.url?scp=85131559588&partnerID=8YFLogxK
U2 - 10.3389/fmolb.2022.891508
DO - 10.3389/fmolb.2022.891508
M3 - Review article
C2 - 35664678
VL - 9
JO - Frontiers in Molecular Biosciences
JF - Frontiers in Molecular Biosciences
SN - 2296-889X
M1 - 891508
ER -
ID: 95037162