Standard

Synthetic Routes to Approved Drugs Containing a Spirocycle. / Moshnenko, Nazar; Kazantsev, Alexander; Chupakhin, Evgeny; Bakulina, Olga; Dar’in, Dmitry.

в: Molecules, Том 28, № 10, 4209, 20.05.2023.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Moshnenko, N, Kazantsev, A, Chupakhin, E, Bakulina, O & Dar’in, D 2023, 'Synthetic Routes to Approved Drugs Containing a Spirocycle', Molecules, Том. 28, № 10, 4209. https://doi.org/10.3390/molecules28104209

APA

Moshnenko, N., Kazantsev, A., Chupakhin, E., Bakulina, O., & Dar’in, D. (2023). Synthetic Routes to Approved Drugs Containing a Spirocycle. Molecules, 28(10), [4209]. https://doi.org/10.3390/molecules28104209

Vancouver

Moshnenko N, Kazantsev A, Chupakhin E, Bakulina O, Dar’in D. Synthetic Routes to Approved Drugs Containing a Spirocycle. Molecules. 2023 Май 20;28(10). 4209. https://doi.org/10.3390/molecules28104209

Author

Moshnenko, Nazar ; Kazantsev, Alexander ; Chupakhin, Evgeny ; Bakulina, Olga ; Dar’in, Dmitry. / Synthetic Routes to Approved Drugs Containing a Spirocycle. в: Molecules. 2023 ; Том 28, № 10.

BibTeX

@article{72ac4eb7a6f14cc9a591959fab64884a,
title = "Synthetic Routes to Approved Drugs Containing a Spirocycle",
abstract = "The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.",
keywords = "spirocycles; three-dimensional; high-Fsp3; spirocyclizations; cyclodehydration; ketalization; intramolecular claisen condensation; intramolecular alkylation; approved drugs, Chemistry, Pharmaceutical, Drug Discovery, intramolecular alkylation, intramolecular claisen condensation, three-dimensional, cyclodehydration, high-Fsp3, ketalization, spirocycles, spirocyclizations, approved drugs",
author = "Nazar Moshnenko and Alexander Kazantsev and Evgeny Chupakhin and Olga Bakulina and Dmitry Dar{\textquoteright}in",
year = "2023",
month = may,
day = "20",
doi = "10.3390/molecules28104209",
language = "English",
volume = "28",
journal = "Molecules",
issn = "1420-3049",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Synthetic Routes to Approved Drugs Containing a Spirocycle

AU - Moshnenko, Nazar

AU - Kazantsev, Alexander

AU - Chupakhin, Evgeny

AU - Bakulina, Olga

AU - Dar’in, Dmitry

PY - 2023/5/20

Y1 - 2023/5/20

N2 - The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.

AB - The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.

KW - spirocycles; three-dimensional; high-Fsp3; spirocyclizations; cyclodehydration; ketalization; intramolecular claisen condensation; intramolecular alkylation; approved drugs

KW - Chemistry, Pharmaceutical

KW - Drug Discovery

KW - intramolecular alkylation

KW - intramolecular claisen condensation

KW - three-dimensional

KW - cyclodehydration

KW - high-Fsp3

KW - ketalization

KW - spirocycles

KW - spirocyclizations

KW - approved drugs

UR - https://www.mdpi.com/1420-3049/28/10/4209

UR - https://www.mendeley.com/catalogue/f1d80472-edbe-3b81-9ad5-d9b6abeeb4dc/

U2 - 10.3390/molecules28104209

DO - 10.3390/molecules28104209

M3 - Review article

C2 - 37241950

VL - 28

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 10

M1 - 4209

ER -

ID: 108598324