Research output: Contribution to journal › Review article › peer-review
Synthetic Routes to Approved Drugs Containing a Spirocycle. / Moshnenko, Nazar; Kazantsev, Alexander; Chupakhin, Evgeny; Bakulina, Olga; Dar’in, Dmitry.
In: Molecules, Vol. 28, No. 10, 4209, 20.05.2023.Research output: Contribution to journal › Review article › peer-review
}
TY - JOUR
T1 - Synthetic Routes to Approved Drugs Containing a Spirocycle
AU - Moshnenko, Nazar
AU - Kazantsev, Alexander
AU - Chupakhin, Evgeny
AU - Bakulina, Olga
AU - Dar’in, Dmitry
PY - 2023/5/20
Y1 - 2023/5/20
N2 - The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.
AB - The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.
KW - spirocycles; three-dimensional; high-Fsp3; spirocyclizations; cyclodehydration; ketalization; intramolecular claisen condensation; intramolecular alkylation; approved drugs
KW - Chemistry, Pharmaceutical
KW - Drug Discovery
KW - intramolecular alkylation
KW - intramolecular claisen condensation
KW - three-dimensional
KW - cyclodehydration
KW - high-Fsp3
KW - ketalization
KW - spirocycles
KW - spirocyclizations
KW - approved drugs
UR - https://www.mdpi.com/1420-3049/28/10/4209
UR - https://www.mendeley.com/catalogue/f1d80472-edbe-3b81-9ad5-d9b6abeeb4dc/
U2 - 10.3390/molecules28104209
DO - 10.3390/molecules28104209
M3 - Review article
C2 - 37241950
VL - 28
JO - Molecules
JF - Molecules
SN - 1420-3049
IS - 10
M1 - 4209
ER -
ID: 108598324