Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis of dendronized polymeric chelating agents using hydrazone ligation strategy. / Polyanichko, Ksenia V.; Chelushkin, Pavel S.; Dorosh, Marina Yu; Gavrilova, Irina I.; Panarin, Evgeny; Dobrodumov, Anatoliy V.; Burov, Sergey V.
в: European Polymer Journal, Том 92, 01.07.2017, стр. 117-125.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis of dendronized polymeric chelating agents using hydrazone ligation strategy
AU - Polyanichko, Ksenia V.
AU - Chelushkin, Pavel S.
AU - Dorosh, Marina Yu
AU - Gavrilova, Irina I.
AU - Panarin, Evgeny
AU - Dobrodumov, Anatoliy V.
AU - Burov, Sergey V.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - A practical protocol has been designed to synthesize dendronized polymeric chelating agents containing 1,4,7,10-tetraazacyclodocecane-N,N′,N″,N′″-tetraacetic acid (DOTA) ligand. The efficiency of suggested approach was verified by grafting of N-vinylpyrrolidone-acrolein P(VP-Ac) copolymer with dendrons containing several DOTA residues as compared to acylation of N-vinylpyrrolidone-vinylamine P(VP-VA) copolymer with active ester of DOTA. It was shown that attachment of pre-synthesized branched building blocks using hydrazone ligation strategy is an efficient method to increase the payload of carrier molecule. A similar methodology was applied for the preparation of polymer grafted by dendrons bearing DOTA complexes with paramagnetic ions (Gd3+ and Mn2+). Obtained results evidenced that polymer-metal complexes possess high relaxivity values and can be considered as promising candidates for MRI contrast agents. The presented results demonstrate utility of hydrazone ligation strategy for the synthesis and screening of dendronized polymeric carriers of different nature.
AB - A practical protocol has been designed to synthesize dendronized polymeric chelating agents containing 1,4,7,10-tetraazacyclodocecane-N,N′,N″,N′″-tetraacetic acid (DOTA) ligand. The efficiency of suggested approach was verified by grafting of N-vinylpyrrolidone-acrolein P(VP-Ac) copolymer with dendrons containing several DOTA residues as compared to acylation of N-vinylpyrrolidone-vinylamine P(VP-VA) copolymer with active ester of DOTA. It was shown that attachment of pre-synthesized branched building blocks using hydrazone ligation strategy is an efficient method to increase the payload of carrier molecule. A similar methodology was applied for the preparation of polymer grafted by dendrons bearing DOTA complexes with paramagnetic ions (Gd3+ and Mn2+). Obtained results evidenced that polymer-metal complexes possess high relaxivity values and can be considered as promising candidates for MRI contrast agents. The presented results demonstrate utility of hydrazone ligation strategy for the synthesis and screening of dendronized polymeric carriers of different nature.
KW - Dendronized polymers
KW - DOTA
KW - Hydrazone ligation
KW - MRI contrast agents
KW - Polymer grafting
UR - http://www.scopus.com/inward/record.url?scp=85018277551&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2017.04.040
DO - 10.1016/j.eurpolymj.2017.04.040
M3 - Article
AN - SCOPUS:85018277551
VL - 92
SP - 117
EP - 125
JO - European Polymer Journal
JF - European Polymer Journal
SN - 0014-3057
ER -
ID: 48335173