DOI

  • Ksenia V. Polyanichko
  • Pavel S. Chelushkin
  • Marina Yu Dorosh
  • Irina I. Gavrilova
  • Evgeny Panarin
  • Anatoliy V. Dobrodumov
  • Sergey V. Burov

A practical protocol has been designed to synthesize dendronized polymeric chelating agents containing 1,4,7,10-tetraazacyclodocecane-N,N′,N″,N′″-tetraacetic acid (DOTA) ligand. The efficiency of suggested approach was verified by grafting of N-vinylpyrrolidone-acrolein P(VP-Ac) copolymer with dendrons containing several DOTA residues as compared to acylation of N-vinylpyrrolidone-vinylamine P(VP-VA) copolymer with active ester of DOTA. It was shown that attachment of pre-synthesized branched building blocks using hydrazone ligation strategy is an efficient method to increase the payload of carrier molecule. A similar methodology was applied for the preparation of polymer grafted by dendrons bearing DOTA complexes with paramagnetic ions (Gd3+ and Mn2+). Obtained results evidenced that polymer-metal complexes possess high relaxivity values and can be considered as promising candidates for MRI contrast agents. The presented results demonstrate utility of hydrazone ligation strategy for the synthesis and screening of dendronized polymeric carriers of different nature.

Язык оригиналаанглийский
Страницы (с-по)117-125
Число страниц9
ЖурналEuropean Polymer Journal
Том92
DOI
СостояниеОпубликовано - 1 июл 2017

    Предметные области Scopus

  • Физика и астрономия (все)
  • Пластик и полимеры
  • Органическая химия

ID: 48335173