Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A practical protocol has been designed to synthesize dendronized polymeric chelating agents containing 1,4,7,10-tetraazacyclodocecane-N,N′,N″,N′″-tetraacetic acid (DOTA) ligand. The efficiency of suggested approach was verified by grafting of N-vinylpyrrolidone-acrolein P(VP-Ac) copolymer with dendrons containing several DOTA residues as compared to acylation of N-vinylpyrrolidone-vinylamine P(VP-VA) copolymer with active ester of DOTA. It was shown that attachment of pre-synthesized branched building blocks using hydrazone ligation strategy is an efficient method to increase the payload of carrier molecule. A similar methodology was applied for the preparation of polymer grafted by dendrons bearing DOTA complexes with paramagnetic ions (Gd3+ and Mn2+). Obtained results evidenced that polymer-metal complexes possess high relaxivity values and can be considered as promising candidates for MRI contrast agents. The presented results demonstrate utility of hydrazone ligation strategy for the synthesis and screening of dendronized polymeric carriers of different nature.
Язык оригинала | английский |
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Страницы (с-по) | 117-125 |
Число страниц | 9 |
Журнал | European Polymer Journal |
Том | 92 |
DOI | |
Состояние | Опубликовано - 1 июл 2017 |
ID: 48335173