Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis and study of antimicrobial activity of bioconjugates of silver nanoparticles and endogenous antibiotics. / Golubeva, O. Yu.; Shamova, O. V.; Orlov, D. S.; Pazina, T. Yu.; Boldina, A. S.; Drozdova, I. A.; Kokryakov, V. N.
в: Glass Physics and Chemistry, Том 37, № 1, 2011, стр. 78-84.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis and study of antimicrobial activity of bioconjugates of silver nanoparticles and endogenous antibiotics
AU - Golubeva, O. Yu.
AU - Shamova, O. V.
AU - Orlov, D. S.
AU - Pazina, T. Yu.
AU - Boldina, A. S.
AU - Drozdova, I. A.
AU - Kokryakov, V. N.
PY - 2011
Y1 - 2011
N2 - Bioconjugates of silver nanoparticles and antimicrobial peptides of the bactenecin family, which are endogenous antibiotics, have been synthesized. The biological activity of the prepared bioconjugates has been evaluated. It has been established that the conjugates of silver nanoparticles with the peptide G-Bac3.4 exhibit an antimicrobial activity, including the activity with respect to the strain Pseudomonas aeruginosa resistant to traditional antibiotics and the strain Staphylococcus aureus (MRSA ATCC 33591) resistant to methicillin. It has been demonstrated that the complexes of silver nanoparticles with antimicrobial peptides do not possess a pronounced membranolytic effect inherent in peptides. The results obtained have made it possible to draw the conclusion that the properties of the synthesized conjugates differ from those characteristic of constituting peptides and silver nanoparticles.
AB - Bioconjugates of silver nanoparticles and antimicrobial peptides of the bactenecin family, which are endogenous antibiotics, have been synthesized. The biological activity of the prepared bioconjugates has been evaluated. It has been established that the conjugates of silver nanoparticles with the peptide G-Bac3.4 exhibit an antimicrobial activity, including the activity with respect to the strain Pseudomonas aeruginosa resistant to traditional antibiotics and the strain Staphylococcus aureus (MRSA ATCC 33591) resistant to methicillin. It has been demonstrated that the complexes of silver nanoparticles with antimicrobial peptides do not possess a pronounced membranolytic effect inherent in peptides. The results obtained have made it possible to draw the conclusion that the properties of the synthesized conjugates differ from those characteristic of constituting peptides and silver nanoparticles.
KW - convergence
KW - bioconjugates
KW - nanoparticles
KW - silver
KW - antimicrobial peptides
KW - antibiotics
KW - PEPTIDE
U2 - 10.1134/S1087659611010056
DO - 10.1134/S1087659611010056
M3 - Article
VL - 37
SP - 78
EP - 84
JO - Glass Physics and Chemistry
JF - Glass Physics and Chemistry
SN - 1087-6596
IS - 1
ER -
ID: 5559399