TY - JOUR

T1 - Sterilizing effect of the mutant allele sbr 10(l(1)ts403) in compound with null allele in Drosophila melanogaster females

AU - Golubkova, E. V.

AU - Pougatcheva, O. M.

AU - Demina, E. P.

AU - Musorina, A. S.

AU - Shershabova, A. N.

AU - Mamon, L. A.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr 10 (l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr 10 (0/sbr 10) at permissive temperature. We studied the contribution to this effects of the following factors: resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr 10. Sterilizing effect of the mutant sbr 10 allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr 10, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr 10 in haploid state to ensure the reproductive functions of Drosophila melanogaster females.

AB - In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr 10 (l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr 10 (0/sbr 10) at permissive temperature. We studied the contribution to this effects of the following factors: resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr 10. Sterilizing effect of the mutant sbr 10 allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr 10, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr 10 in haploid state to ensure the reproductive functions of Drosophila melanogaster females.

UR - http://www.scopus.com/inward/record.url?scp=9444254098&partnerID=8YFLogxK

U2 - 10.1023/B:RUGE.0000024973.95306.b5

DO - 10.1023/B:RUGE.0000024973.95306.b5

M3 - Article

C2 - 15174279

AN - SCOPUS:16544376889

VL - 40

SP - 369

EP - 376

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 4

ER -