In females of Df(1)v-L4/+(0/+) genotype, the presence of the wild-type allele of small bristles (sbr) gene in a single dose has no significant effect on their fecundity, whereas a reduced dose of the temperature-sensitive allele sbr ¹⁰ (l(1)ts403) causes a strong sterilizing effect in females Df(1)v-L4/sbr ¹⁰ (0/sbr ¹⁰) at permissive temperature. We studied the contribution to this effects of the following factors: resorption of egg chambers, decreased oviposition, offspring death at the embryonic and larval stages, and reduced fecundity in females 0/sbr ¹⁰. Sterilizing effect of the mutant sbr ¹⁰ allele proved to be primarily caused by offspring lethality at the embryonic and first-instar larval stages. In 0/+ females, the majority of undeveloped eggs contained embryos that perished at the late developmental stages, whereas in females 0/sbr ¹⁰, at least 50% of undeveloped egg showed no visible signs of development or the embryo development was arrested at early stages of embryogenesis. The results obtained suggest insufficiency of the temperature-sensitive allele sbr ¹⁰ in haploid state to ensure the reproductive functions of Drosophila melanogaster females.