Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A new format for the Castagnoli-Cushman reaction of structurally diverse dicarboxylic acids, amines, and aldehydes in the presence of acetic anhydride as dehydrating agent is described. The reaction is distinctly amenable to parallel format: the combinatorial array of 180 reactions delivered 157 products of >85% purity without chromatographic purification (of this number, 143 compounds had >94% purity). The new method offers a convenient preparation of the skeletally and peripherally diverse, lead- and druglike β- and β-lactam carboxylic acids with high diastereoselectivity in combinatorial fashion.
Язык оригинала | английский |
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Страницы (с-по) | 702-707 |
Число страниц | 6 |
Журнал | ACS Combinatorial Science |
Том | 19 |
Номер выпуска | 11 |
DOI | |
Состояние | Опубликовано - 13 ноя 2017 |
ID: 34634267