Research output: Contribution to journal › Article › peer-review
A new format for the Castagnoli-Cushman reaction of structurally diverse dicarboxylic acids, amines, and aldehydes in the presence of acetic anhydride as dehydrating agent is described. The reaction is distinctly amenable to parallel format: the combinatorial array of 180 reactions delivered 157 products of >85% purity without chromatographic purification (of this number, 143 compounds had >94% purity). The new method offers a convenient preparation of the skeletally and peripherally diverse, lead- and druglike β- and β-lactam carboxylic acids with high diastereoselectivity in combinatorial fashion.
Original language | English |
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Pages (from-to) | 702-707 |
Number of pages | 6 |
Journal | ACS Combinatorial Science |
Volume | 19 |
Issue number | 11 |
DOIs | |
State | Published - 13 Nov 2017 |
ID: 34634267