Using voltage-clamp technique, the involvement of sigma-1 receptors in the regulation of Na+
transport in frog skin by the immunomodulatory drug glutoxim was investigated. We have shown for the first
time that preincubation of the frog skin with the sigma-1 receptor antagonists haloperidol and chlorpromazine
attenuates the stimulatory effect of glutoxim on the Na+ transport. The results suggest the possible
involvement of the sigma-1 receptors in the regulation of Na+ transport in frog skin epithelium by glutoxim.
DOI: 10.1134/S1607672919010186