Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia

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Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia. / Shumilova, T.E.; Shereshkov, V.I.; Nozdrachev, A.D.

в: Biology Bulletin, Том 39, № 6, 2012, стр. 547-555.

Результаты исследований: Научные публикации в периодических изданиях › статья

BibTeX

@article{6daeb84ee7a74554ade6e0b869f96609,

title = "Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia",

abstract = "Abstract—Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the reninangiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process.",

author = "T.E. Shumilova and V.I. Shereshkov and A.D. Nozdrachev",

year = "2012",

doi = "10.1134/S106235901206012X",

language = "English",

volume = "39",

pages = "547--555",

journal = "Biology Bulletin",

issn = "1062-3590",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "6",

}

RIS

TY - JOUR

T1 - Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia

AU - Shumilova, T.E.

AU - Shereshkov, V.I.

AU - Nozdrachev, A.D.

PY - 2012

Y1 - 2012

N2 - Abstract—Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the reninangiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process.

AB - Abstract—Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the reninangiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process.

U2 - 10.1134/S106235901206012X

DO - 10.1134/S106235901206012X

M3 - Article

VL - 39

SP - 547

EP - 555

JO - Biology Bulletin

JF - Biology Bulletin

SN - 1062-3590

IS - 6

ER -

ID: 5351588