Research output: Contribution to journal › Article
Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia. / Shumilova, T.E.; Shereshkov, V.I.; Nozdrachev, A.D.
In: Biology Bulletin, Vol. 39, No. 6, 2012, p. 547-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of Peripheral and Systemic Blood Circulation in Rats in Conditions of Acute Nitrite Hypoxia
AU - Shumilova, T.E.
AU - Shereshkov, V.I.
AU - Nozdrachev, A.D.
PY - 2012
Y1 - 2012
N2 - Abstract—Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the reninangiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process.
AB - Abstract—Regulation of the systemic and peripheral hemodynamics in the conditions of acute nitrite hypoxia (doses of NaNO2 10, 30, and 50 mg/kg of the body mass) were studied on white male rats. It was shown that NaNO2 causes a quick dose-dependent decrease in the blood pressure with an intensification of the parasympathetic tonus and development of bradycardia. The hemodynamics was restored as the oxygen capacity of the blood decreased with an increase in the sympathetic tonus and development of tachycardia. The role of intracardial metasympathetic structures and the reninangiotensin system in cardiovascular adaptation to hypoxia was established. Adaptation to nitrite hypoxia is accomplished by a coordinated interaction of neurogenic and humoral factors. A combination of pharmacological agents, which include separate links of regulator systems of the organism, leads to failure of the adaptation process.
U2 - 10.1134/S106235901206012X
DO - 10.1134/S106235901206012X
M3 - Article
VL - 39
SP - 547
EP - 555
JO - Biology Bulletin
JF - Biology Bulletin
SN - 1062-3590
IS - 6
ER -
ID: 5351588