Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Quality Control of Heparin Injections : Comparison of Four Established Methods. / Burmistrova, Natalia A.; Diehl, Bernd W.K.; Soboleva, Polina M.; Rubtsova, Ekaterina; Legin, Eugene A.; Legin, Andrey V.; Kirsanov, Dmitry O.; Monakhova, Yulia B.
в: Analytical Sciences, Том 36, № 12, 2020, стр. 1467-1472.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Quality Control of Heparin Injections
T2 - Comparison of Four Established Methods
AU - Burmistrova, Natalia A.
AU - Diehl, Bernd W.K.
AU - Soboleva, Polina M.
AU - Rubtsova, Ekaterina
AU - Legin, Eugene A.
AU - Legin, Andrey V.
AU - Kirsanov, Dmitry O.
AU - Monakhova, Yulia B.
N1 - Funding Information: This work was supported by the Russian Science Foundation (project 18-73-10009). Publisher Copyright: 2020 © The Japan Society for Analytical Chemistry Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.
AB - Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.
KW - heparin
KW - injections
KW - principal component analysis
KW - sensors
KW - Spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=85097246416&partnerID=8YFLogxK
U2 - 10.2116/analsci.20P214
DO - 10.2116/analsci.20P214
M3 - Article
C2 - 32801287
AN - SCOPUS:85097246416
VL - 36
SP - 1467
EP - 1472
JO - Analytical Sciences
JF - Analytical Sciences
SN - 0910-6340
IS - 12
ER -
ID: 73233246