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Quality Control of Heparin Injections : Comparison of Four Established Methods. / Burmistrova, Natalia A.; Diehl, Bernd W.K.; Soboleva, Polina M.; Rubtsova, Ekaterina; Legin, Eugene A.; Legin, Andrey V.; Kirsanov, Dmitry O.; Monakhova, Yulia B.

In: Analytical Sciences, Vol. 36, No. 12, 2020, p. 1467-1472.

Research output: Contribution to journal › Article › peer-review

Harvard

Burmistrova, NA, Diehl, BWK, Soboleva, PM, Rubtsova, E, Legin, EA, Legin, AV, Kirsanov, DO & Monakhova, YB 2020, 'Quality Control of Heparin Injections: Comparison of Four Established Methods', Analytical Sciences, vol. 36, no. 12, pp. 1467-1472. https://doi.org/10.2116/analsci.20P214

APA

Burmistrova, N. A., Diehl, B. W. K., Soboleva, P. M., Rubtsova, E., Legin, E. A., Legin, A. V., Kirsanov, D. O., & Monakhova, Y. B. (2020). Quality Control of Heparin Injections: Comparison of Four Established Methods. Analytical Sciences, 36(12), 1467-1472. https://doi.org/10.2116/analsci.20P214

Vancouver

Burmistrova NA, Diehl BWK, Soboleva PM, Rubtsova E, Legin EA, Legin AV et al. Quality Control of Heparin Injections: Comparison of Four Established Methods. Analytical Sciences. 2020;36(12):1467-1472. https://doi.org/10.2116/analsci.20P214

Author

Burmistrova, Natalia A. ; Diehl, Bernd W.K. ; Soboleva, Polina M. ; Rubtsova, Ekaterina ; Legin, Eugene A. ; Legin, Andrey V. ; Kirsanov, Dmitry O. ; Monakhova, Yulia B. / Quality Control of Heparin Injections : Comparison of Four Established Methods. In: Analytical Sciences. 2020 ; Vol. 36, No. 12. pp. 1467-1472.

BibTeX

@article{2b6a981bf2b4448d96640466ef6c3c5e,
title = "Quality Control of Heparin Injections: Comparison of Four Established Methods",
abstract = "Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.",
keywords = "heparin, injections, principal component analysis, sensors, Spectroscopy",
author = "Burmistrova, {Natalia A.} and Diehl, {Bernd W.K.} and Soboleva, {Polina M.} and Ekaterina Rubtsova and Legin, {Eugene A.} and Legin, {Andrey V.} and Kirsanov, {Dmitry O.} and Monakhova, {Yulia B.}",
note = "Funding Information: This work was supported by the Russian Science Foundation (project 18-73-10009). Publisher Copyright: 2020 {\textcopyright} The Japan Society for Analytical Chemistry Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.2116/analsci.20P214",
language = "English",
volume = "36",
pages = "1467--1472",
journal = "Analytical Sciences",
issn = "0910-6340",
publisher = "Japan Society for Analytical Chemistry",
number = "12",

}

RIS

TY - JOUR

T1 - Quality Control of Heparin Injections

T2 - Comparison of Four Established Methods

AU - Burmistrova, Natalia A.

AU - Diehl, Bernd W.K.

AU - Soboleva, Polina M.

AU - Rubtsova, Ekaterina

AU - Legin, Eugene A.

AU - Legin, Andrey V.

AU - Kirsanov, Dmitry O.

AU - Monakhova, Yulia B.

N1 - Funding Information: This work was supported by the Russian Science Foundation (project 18-73-10009). Publisher Copyright: 2020 © The Japan Society for Analytical Chemistry Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.

AB - Heparin is an anticoagulant medication that is usually injected subcutaneously. The quality of a set of commercial heparin injections from different producers was examined by NMR, IR, UV-Vis spectroscopies and potentiometric multisensor system. The type of raw material regarding heparin animal origin and producer, heparin molecular weight and activity values were derived based on the non-targeted analysis of 1H NMR fingerprints. DOSY NMR spectroscopy was additionally used to study homogeneity and additives profile. UV-Vis and IR, being cheaper than NMR, combined with multivariate statistics were successfully applied to study excipients composition as well as semi-estimation of activity values. Potentiometric multisensor measurements were found to be an important additional source of information about inorganic composition of finished heparin formulations. All investigated instrumental techniques are useful for finished heparin injections and should be selected according to availability as well as the information and confidence required for a specific sample.

KW - heparin

KW - injections

KW - principal component analysis

KW - sensors

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85097246416&partnerID=8YFLogxK

U2 - 10.2116/analsci.20P214

DO - 10.2116/analsci.20P214

M3 - Article

C2 - 32801287

AN - SCOPUS:85097246416

VL - 36

SP - 1467

EP - 1472

JO - Analytical Sciences

JF - Analytical Sciences

SN - 0910-6340

IS - 12

ER -

ID: 73233246